-ketoglutaric

Cofftek muaj lub peev xwm rau huab hwm coj ntau lawm thiab muab khoom ntawm Calcium 2-oxoglutarate thiab Alpha-Ketoglutaric Acid nyob rau hauv qhov xwm txheej ntawm cGMP.

Cofttek chij

Yuav Urolithin hmoov

Alpha-Ketoglutaric Acid (328-50-7) yog dab tsi?

Alpha-ketoglutaric acid yog lub chaw lom tsiaj nyob hauv tib neeg lub cev. Kuj tseem muaj raws li kev noj zaub mov ntxiv, alpha-ketoglutaric acid ua lub luag haujlwm tseem ceeb hauv Krebs phaum (cov tshuaj siv tshuaj uas siv los tso cov zog). Alpha-ketoglutaric acid pab ntxiv yog muab rau muaj ntau cov txiaj ntsig kev noj qab haus huv, suav nrog kev ua kom muaj zog ntawm cov kis las thiab txhim kho cov metabolism.

Alpha-Ketoglutaric Acid (328-50-7) cov txiaj ntsig

Nrog rau qhov ntawd tau hais, ob peb qhov kev tshawb fawb thaum ntxov tau qhia qhov tseeb ntawm cov txiaj ntsig zoo ntawm alpha-ketoglutaric acid ntxiv. Nov yog qee qhov kev tshawb fawb niaj hnub no hais tias:
① Keeb Kwm Mob raum
Alpha-ketoglutaric acid tau siv txij li xyoo 1990s los pab zom thiab nqus cov protein hauv cov neeg ntawm hemodialysis uas xav tau cov zaub mov muaj protein tsawg. Cov pov thawj tsis ntev los no qhia tau hais tias nws kuj tseem tuaj yeem ncua qhov xav tau rau kev lim ntshav hauv cov neeg uas muaj kab mob raum ntev (CKD).

(1) ↗

Cov neeg ntseeg siab tau

PubMed Central

Kev hwm cov ntaub ntawv los ntawm National Institutes of Health
Mus rau qhov chaw

Raws li kev tshawb fawb xyoo 2017 hauv phau ntawv Journal PLoS One, cov kws tshawb fawb tau txheeb xyuas thiab ua raws li 1,483 tus neeg uas muaj CKD siab heev uas tau siv cov tshuaj alpha-ketoglutaric acid ntxiv hu ua Ketosteril. Lub sijhawm nruab nrab ntawm kev soj ntsuam yog 1.57 xyoo.
Piv nrog rau cov txheej txheem sib txuam ntawm cov tib neeg uas tsis tau noj cov tshuaj ntxiv, cov uas ua tau tsawg dua yuav tsum tau lim ntshav mus ntev. Cov txiaj ntsig txuas ntxiv tsuas yog rau cov neeg uas tau noj ntau dua 5.5 ntsiav tshuaj ib hnub, qhia tias cov txiaj ntsig tau nyob ntawm koob tshuaj.
Txawm hais tias qhov kev tshawb pom zoo, nws tsis paub meej tias lub luag haujlwm alpha-ketoglutaric acid ua si li cas hauv kev sib piv rau cov tshuaj ntxiv rau lwm cov khoom xyaw. Xav tau kev tshawb fawb ntxiv.

AstTxoj Kev Noj Qab Haus Huv Huv
Cov tshuaj Alpha-ketoglutaric acid tau ntseeg tias yog anticatabolic, txhais tau tias nws qeeb lossis tiv thaiv lossis catabolism (kev tawg ntawm cov ntaub so ntswg). Los ntawm kev txhais, cov txheej txheem catabolic yog qhov sib txawv rau cov txheej txheem anabolic (hauv cov ntaub so ntswg tsim).
Ib txoj kev tshawb fawb xyoo 2012 nyob rau hauv Italian Journal of Animal Science tau tshaj tawm tias alpha-ketoglutaric acid tiv thaiv kev zom cov hnyuv hauv cov nas uas tau noj cov zaub mov tsis muaj protein ntau rau 14 hnub. Ntau dua li muaj kev puas tsuaj rau cov ntiv tes zoo li villi ntawm txoj hnyuv - qhov kev xav tau - cov nas noj alpha-ketoglutaric acid tsis pom kev puas tsuaj piv rau cov nas uas tsis yog.
Ntxiv mus, cov nas muab cov tshuaj muaj peev xwm tswj tau qhov kev loj hlob zoo txawm tias tag nrho cov tsis muaj protein ntau. Cov koob tshuaj ntau dua tau txais txiaj ntsig zoo dua.
Cov kev tshawb pom zoo li txhawb nqa alpha-ketoglutaric acid cov teebmeem anticatabolic. Ntxiv nrog rau nws daim ntawv thov hauv cov kab mob raum ntev, alpha-ketoglutaric acid kuj tseem tuaj yeem pab cov neeg mob plab hnyuv toxemia thiab malabsorption mob xws li kab mob celiac. Xav tau kev tshawb fawb ntxiv.

③Athletic Kev Ua Haujlwm
Los ntawm qhov sib txawv, cov teebmeem anticatabolic ntawm alpha-ketoglutaric acid tshwm sim luv luv thaum siv rau lub hom phiaj ntawm kev loj hlob ntawm cov leeg thiab kev ua kis las.
Raws li kev tshawb fawb xyoo 2012 hauv Phau Ntawv Xov Xwm ntawm International Society of Sports Nutrition, alpha-ketoglutaric acid tsis muaj kev cuam tshuam rau cov leeg nqaij lossis kev tawm dag zog hauv 16 tus txiv neej ua haujlwm nrog kev tawm dag zog ua haujlwm.

(2) ↗

Cov neeg ntseeg siab tau

PubMed Central

Kev hwm cov ntaub ntawv los ntawm National Institutes of Health
Mus rau qhov chaw

Rau txoj kev tshawb no, ib nrab ntawm cov txiv neej tau muab 3,000-milligrams (mg) ntawm alpha-ketoglutaric acid, thaum lwm tus ib nrab tau muab cov placebo 45 feeb ua ntej ua lub rooj ntev zaum xovxwm thiab ceg xovxwm. Lub lim tiam tom ntej, cov tshuaj tau hloov pauv, nrog txhua ib nrab tau txais cov tshuaj hloov pauv.
Kev ua kis las tau ua raws li tag nrho cov ntim ntim (TLV) ntawm cov kev tawm dag zog uas tau ua hauv tandem nrog lub plawv dhia ua ntej thiab tom qab qoj ib ce. Qhov kev tshawb pom no qhia tau tias yog qhov tsis muaj cov lus teb catabolic tsis yog tib yam li cov lus teb anabolic, tshwj xeeb tshaj yog cov kis las.

Alpha-Ketoglutaric Acid (328-50-7) siv?

Hauv kev phais plawv, alpha-ketoglutaric acid qee zaum xa mus rau hauv cov hlab ntsha (rau hauv cov hlab ntsha) kom txo qis kev puas tsuaj rau lub plawv cov leeg vim qhov txo qis hauv cov ntshav. Ua li no kuj tseem tuaj yeem txhim kho cov ntshav khiav mus rau lub raum tom qab kev phais.
Nws siv raws li ib tug ntxiv yog tsis tshua muaj tseeb. Lwm cov kws kho mob ntseeg tias alpha-ketoglutaric acid tuaj yeem kho lossis tiv thaiv ntau yam mob, suav nrog:
  • cataracts
  • Mob raum kab mob
  • Hepatomegaly (mob siab)
  • Mob plab hnyuv tws
  • Qhov ncauj tawm
  • txha
  • Tendinopathy
  • Poov xab kis
Vim tias nws lub luag haujlwm hauv kev tso tawm lub zog cia, alpha-ketoglutaric acid feem ntau yog muag raws li kev ua kis las ntxiv. Qee cov neeg txhawb nqa txawm hais tias cov tshuaj ntxiv cov teebmeem antioxidant tuaj yeem ua rau kev laus qeeb.

(3) ↗

Cov neeg ntseeg siab tau

PubMed Central

Kev hwm cov ntaub ntawv los ntawm National Institutes of Health
Mus rau qhov chaw

Raws li feem ntau cov ntaub ntawv nrog cov tshuaj uas tau thov los kho ntau yam tsis sib xws, cov pov thawj txhawb nqa cov lus thov no tsis muaj zog. Qee qhov, zoo li cov khoom ntxiv "tiv thaiv kev laus" (raws li kev tshawb fawb 2014 feem ntau cuam tshuam nrog cov kab mob nematode), ciam teb ntawm qhov tsis tuaj yeem.

Alpha-Ketoglutaric Acid (328-50-7) ntau npaum li cas

Cov tshuaj Alpha-ketoglutaric acid muaj nyob rau hauv cov ntsiav tshuaj, tshuaj ntsiav, thiab hmoov formulations thiab tuaj yeem pom hauv online lossis hauv khw muag khoom tshwj xeeb hauv kev noj zaub mov.
Tsis muaj cov lus qhia dav dav rau kev siv cov alpha-ketoglutaric acids uas tsim nyog. Cov tshuaj ntxiv yog muag hauv ntau npaum li ntawm 300 milligrams (mg) txog 1,000 mg noj ib hnub ib zaug nrog lossis tsis muaj zaub mov. Cov koob tshuaj txog li 3,000 mg tau siv rau hauv cov kev tshawb fawb uas tsis muaj qhov cuam tshuam.

Alpha-Ketoglutaric Acid (328-50-7) cov kev mob tshwm sim

Alpha-ketoglutaric acid yog suav hais tias muaj kev nyab xeeb thiab ua tau zoo. Cov kev tshawb fawb soj ntsuam cov teebmeem ntawm alpha-ketoglutaric acid tau tshaj tawm qee cov tsos mob tshwm sim tom qab peb xyoos ntawm kev siv.
Raws li cov khoom sib xyaw ua los ntawm cov amino acids tsis tseem ceeb, alpha-ketoglutaric acid tsis yog ib yam khoom uas koj tuaj yeem nkag tau ntau dhau. Ib qho dhau ntawm lub cev yuav raug tso tawm hauv cov zis los yog tawg mus rau hauv cov amino acid lub tsev blocks rau lwm lub hom phiaj.

(4) ↗

Cov neeg ntseeg siab tau

PubMed Central

Kev hwm cov ntaub ntawv los ntawm National Institutes of Health
Mus rau qhov chaw

Nrog rau qhov hais tias, kev nyab xeeb ntawm alpha-ketoglutaric acid hauv cov poj niam cev xeeb tub, niam laus, thiab menyuam yaus tsis tau tsim. Qhov no suav nrog cov menyuam yaus uas muaj cov kab mob metabolism tsawg xws li alpha-ketoglutarate dehydrogenase deficiency (nyob rau hauv uas cov qib alpha-ketoglutaric acid yog qhov txawv txav).

Alpha-Ketoglutaric Acid hmoov rau muag (Qhov Chaw Yuav Alpha-Ketoglutaric Acid hmoov hauv qhov loj)

Peb lub tuam txhab txaus siab rau kev sib raug zoo ntev nrog peb cov neeg vim tias peb tsom mus rau cov neeg siv khoom thiab muab cov khoom zoo. Yog tias koj txaus siab rau peb cov khoom lag luam, peb yoog tau nrog kho kom haum cov kev txiav txim siab kom haum koj cov kev xav tau tshwj xeeb thiab peb lub sijhawm ceev ceev ntawm kev txiav txim tau lees tias koj yuav tau saj zoo peb cov khoom kom raws sijhawm. Peb kuj tseem tsom rau kev pabcuam ntxiv tus nqi. Peb muaj nyob rau cov lus nug kev pabcuam thiab cov ntaub ntawv los txhawb koj txoj kev lag luam.
Peb yog ib tus kws tshaj lij Alpha-Ketoglutaric Acid hmoov cov khoom lag luam rau ntau xyoo, peb muab cov khoom lag luam nrog cov nqi sib tw, thiab peb cov khoom yog cov khoom zoo tshaj plaws thiab dhau mus nruj, kev sim ywj pheej los xyuas kom meej tias nws muaj kev nyab xeeb rau kev noj thoob ntiaj teb.

reference:

  1. Abrahams JP, Leslie AG, Lutter R, Walker JE. Tus qauv ntawm 2.8 Ib qho kev daws teeb meem ntawm F1-ATPase los ntawm bovine lub plawv mitochondria. Xwm. Xyoo 1994; 370: 621–628. doi: 10.1038 / 370621a0.
  2. Alpers DH. Glutamine: ua cov ntaub ntawv txhawb rau qhov ua rau glutamine ntxiv rau tib neeg? Lub plab zom mov. 2006; 130: S106 – S116. doi: 10.1053 / j.gastro.2005.11.049.
  3. Ashkanazi J, Carpertier Y, Michelsen C. Nqaij thiab ntshav amino acids tom qab raug mob. Ann Surg. 1980; 192: 78–85. doi: 10.1097 / 00000658-198007000-00014.