-ketoglutaric

Cofftek muaj lub peev xwm rau huab hwm coj ntau lawm thiab muab khoom ntawm Calcium 2-oxoglutarate thiab Alpha-Ketoglutaric Acid nyob rau hauv qhov xwm txheej ntawm cGMP.

Alpha-Ketoglutaric Acid (328-50-7) yog dab tsi?

Alpha-ketoglutaric acid yog lub chaw lom tsiaj nyob hauv tib neeg lub cev. Kuj tseem muaj raws li kev noj zaub mov ntxiv, alpha-ketoglutaric acid ua lub luag haujlwm tseem ceeb hauv Krebs phaum (cov tshuaj siv tshuaj uas siv los tso cov zog). Alpha-ketoglutaric acid pab ntxiv yog muab rau muaj ntau cov txiaj ntsig kev noj qab haus huv, suav nrog kev ua kom muaj zog ntawm cov kis las thiab txhim kho cov metabolism.

Alpha-Ketoglutaric Acid (328-50-7) cov txiaj ntsig

Nrog rau qhov ntawd tau hais, ob peb qhov kev tshawb fawb thaum ntxov tau qhia qhov tseeb ntawm cov txiaj ntsig zoo ntawm alpha-ketoglutaric acid ntxiv. Nov yog qee qhov kev tshawb fawb niaj hnub no hais tias:
① Keeb Kwm Mob raum
Alpha-ketoglutaric acid tau siv txij li lub sijhawm xyoo 1990 los pab rhuav tshem thiab nqus cov protein ntau hauv cov neeg ntawm hemodialysis uas xav tau kev noj zaub mov muaj protein tsawg. Cov ntaub ntawv pov thawj tsis ntev los no qhia tau tias nws tseem tuaj yeem ncua qhov kev xav tau rau kev lim ntshav hauv cov neeg muaj mob raum ntev (CKD). Raws li kev tshawb pom 2017 nyob rau hauv phau ntawv xov xwm PLoS Ib, cov kws tshawb nrhiav tau txheeb xyuas thiab ua raws li 1,483 cov neeg uas muaj CKD qib siab uas siv alpha-ketoglutaric acid ntxiv hu ua Ketosteril. Lub sijhawm nruab nrab ntawm kev rov qab taug qab yog 1.57 xyoo. Muab piv rau cov sib piv ntawm cov tib neeg uas tsis noj cov tshuaj ntxiv, cov tsis ua zoo li yuav tsum tau lim ntshav ntev. Cov txiaj ntsig tau ntxiv rau cov neeg uas tau siv ntau tshaj 5.5 ntsiav tshuaj nyob rau ib hnub, qhia tias cov kev cuam tshuam tau siv tshuaj ntau. Txawm hais tias pom qhov kev tshawb pom zoo, nws tsis paub meej lub luag haujlwm alpha-ketoglutaric acid ua si nyob rau hauv kev sib piv rau cov tshuaj ntxiv lwm cov tshuaj xyaw. Tseem muaj kev tshawb nrhiav ntxiv.

AstTxoj Kev Noj Qab Haus Huv Huv
Alpha-ketoglutaric acid pab ntseeg tau tias yog anticatabolic, txhais tau hais tias nws qeeb qeeb lossis tiv thaiv lossis catabolism (rhuav tshem cov ntaub so ntswg). Los ntawm txhais tau tias, cov txheej txheem catabolic yog txawv rau cov txheej txheem anabolic (hauv cov ntaub so ntswg no yog tsim). Kev tshawb nrhiav xyoo 2012 hauv Italian Lub Chaw Tshawb Fawb Tsiaj tau tshaj tawm tias alpha-ketoglutaric acid tiv thaiv kev mob plab hnyuv hauv cov nas ua cov khoom noj muaj protein ntau kom tsis pub dhau 14 hnub. Tsis yog muaj kev puas tsuaj rau cov ntiv tes zoo li villi ntawm cov hnyuv - qhov xav kom tshwm sim - cov nas uas noj alpha-ketoglutaric acid tsis pom muaj kev puas tsuaj piv rau cov nas uas tsis yog. Ntxiv mus, cov nas uas muab cov pabcuam tau tuaj yeem tswj hwm kev loj hlob zoo dua li lub sijhawm tsis muaj protein tsawg. Kev txhaj tshuaj ntau dua muab rau cov txiaj ntsig zoo dua. Qhov pom pom tshwm los txhawb alpha-ketoglutaric acid cov teebmeem anticatabolic. Ntxiv nrog rau nws cov ntawv thov hauv kev mob raum ntev, alpha-ketoglutaric acid kuj tseem yuav pab cov tib neeg muaj mob plab hnyuv thiab ua kom tsis haum ntshav zoo li kab mob celiac. Tseem muaj kev tshawb nrhiav ntxiv.

③Athletic Kev Ua Haujlwm
Ntawm qhov tsis sib xws, cov teebmeem anticatabolic ntawm alpha-ketoglutaric acid tshwm sim poob qis thaum siv rau lub hom phiaj ntawm cov leeg mob thiab kev ua kis las. Raws li kev tshawb nrhiav xyoo 2012 hauv phau ntawv Journal ntawm International Society ntawm Cov Khoom Noj Kom Ncaws Pob, alpha-ketoglutaric acid tsis muaj qhov cuam tshuam rau ntawm cov leeg nqaij lossis lub dag lub zog ntawm 16 tus txiv neej ua haujlwm nrog kev tawm tsam kev tawm tsam. Rau qhov kev tshawb fawb no, ib nrab ntawm cov txiv neej tau muab 3,000-milligrams (mg) ntawm alpha-ketoglutaric acid, thaum ib nrab tau muab cov placebo 45 feeb ua ntej ua cov nias xovxwm thiab ceg nias ce. Lub lim tiam tom qab no, cov tshuaj tau hloov tawm, nrog txhua ib nrab tau txais lwm txoj kev siv tshuaj. Kev ua kis las yog ua raws li tag nrho cov kev ntim (TLV) ntawm cov kev tawm dag zog uas ua hauv lub cev nrog lub plawv ua ntej thiab tom qab ua si. Dab tsi cov kev tshawb pom no ua rau pom tsis muaj qhov kev teb catabolic tsis zoo tib yam li teb anabolic, tshwj xeeb yog ntawm cov neeg ncaws pob.

Alpha-Ketoglutaric Acid (328-50-7) siv?

Hauv kev phais plawv, alpha-ketoglutaric acid qee zaum xa rau cov leeg (mus rau hauv cov leeg ntshav) txhawm rau txo kev puas tsuaj rau cov leeg mob plawv vim tias cov ntshav ntws tsawg. Ua li ntawd kuj tseem tuaj yeem txhim kho ntshav txaus rau lub raum tom qab qhov kev phais mob. Nws siv raws li kev txhawb ntxiv yog qhov tsis tshua meej. Lwm cov kws qhia kev ntseeg ntseeg hais tias alpha-ketoglutaric acid tuaj yeem kho lossis tiv thaiv ntau yam mob hauv qab no, suav nrog:
  • cataracts
  • Mob raum kab mob
  • Hepatomegaly (mob siab)
  • Mob plab hnyuv tws
  • Qhov ncauj tawm
  • txha
  • Tendinopathy
  • Poov xab kis
Vim tias nws lub luag haujlwm hauv kev tso tawm cov hluav taws xob khaws cia, alpha-ketoglutaric acid feem ntau tau ua lag luam raws li kev ua kis las ncaws pob ntxiv. Qee cov neeg tshaj tawm hais tias qhov ntxiv ntawm cov antioxidant los cuam tshuam yuav ua rau kev laus qeeb. Raws li ib txwm muaj qhov xwm txheej nrog cov tshuaj uas tau hais kom kho ntau yam tsis muaj kev cuam tshuam, cov pov thawj txhawb cov kev thov tsis muaj zog. Qee tus, xws li cov khoom ntxiv "los tiv thaiv kev laus" lub zog (raws qhov kev tshawb fawb loj 2014 nrog nematode cua nab), ciam teb ntawm qhov tsis tsim nyog.

Alpha-Ketoglutaric Acid (328-50-7) ntau npaum li cas

Alpha-ketoglutaric acid pab muaj nyob rau hauv cov ntsiav tshuaj, tshuaj ntsiav, thiab cov hmoov tsim thiab muaj peev xwm nrhiav tau online online lossis hauv cov khw muag khoom noj tshwj xeeb hauv kev noj zaub mov zoo. Tsis muaj cov lus qhia thoob ntiaj teb rau kev siv cov tshuaj alpha-ketoglutaric acids uas tsim nyog. Cov tshuaj ntxiv feem ntau muag hauv ntau npaum li ntawm 300 milligrams (mg) txog 1,000 mg noj ib hnub ib zaug nrog lossis tsis noj mov. Cov koob tshuaj txog li 3,000 mg tau siv rau hauv kev kawm tsis muaj kev cuam tshuam zoo.

Alpha-Ketoglutaric Acid (328-50-7) cov kev mob tshwm sim

Alpha-ketoglutaric acid yog suav hais tias muaj kev nyab xeeb thiab muaj kev tiv thaiv zoo. Cov kev tshawb nrhiav soj ntsuam qhov cuam tshuam ntawm alpha-ketoglutaric acid qhia ob peb cov kev mob tshwm sim tom qab peb xyoos siv. Raws li lub tebchaw ua los ntawm cov tsis tseem ceeb amino acids, alpha-ketoglutaric acid tsis yog cov khoom uas koj tuaj yeem nkag tau dhau. Ib yam dhau mus hauv lub cev yuav raug cais tawm hauv cov zis lossis muab zom rau hauv cov amino acid lub tsev pob zeb rau lwm yam. Nrog cov lus hais ntawd, kev nyab xeeb ntawm alpha-ketoglutaric acid nyob rau hauv cov poj niam cev xeeb tub, cov niam laus, thiab cov menyuam tseem tsis tau tsim. Qhov no suav nrog cov menyuam yaus uas tsis tshua muaj cov metabolism hauv lub cev xws li alpha-ketoglutarate dehydrogenase tsis muaj peev xwm (qhov uas alpha-ketoglutaric acid muaj feem ntau tsis txaus siab).

Alpha-Ketoglutaric Acid hmoov rau muag (Qhov Chaw Yuav Alpha-Ketoglutaric Acid hmoov hauv qhov loj)

Peb lub tuam txhab txaus siab rau kev sib raug zoo ntev nrog peb cov neeg vim tias peb tsom mus rau cov neeg siv khoom thiab muab cov khoom zoo. Yog tias koj txaus siab rau peb cov khoom lag luam, peb yoog tau nrog cov kev cai txiav txim siab kom haum koj cov kev xav tau tshwj xeeb thiab peb lub sij hawm taug txhuas ceev ntawm kev txiav txim tau lees tias koj yuav tau saj zoo peb cov khoom kom raws sijhawm. Peb kuj tseem tsom rau kev pabcuam ntxiv tus nqi. Peb muaj nyob rau cov lus nug kev pabcuam thiab cov ntaub ntawv los txhawb koj txoj kev lag luam. Peb yog tus kws tshaj lij Alpha-Ketoglutaric Acid hmoov tsum rau ntau xyoo, peb muab cov khoom lag luam nrog cov nqi sib tw, thiab peb cov khoom yog qhov ua tau zoo tshaj plaws thiab yauv mus kuaj kev ywj pheej, kom ntseeg tau tias nws muaj kev nyab xeeb rau noj thoob ntiaj teb.

reference:

  1. Abrahams JP, Leslie AG, Lutter R, Walker JE. Tus qauv ntawm 2.8 Ib qho kev daws teeb meem ntawm F1-ATPase los ntawm bovine lub plawv mitochondria. Xwm. Xyoo 1994; 370: 621–628. doi: 10.1038 / 370621a0.
  2. Alpers DH. Glutamine: ua cov ntaub ntawv txhawb rau qhov ua rau glutamine ntxiv rau tib neeg? Lub plab zom mov. 2006; 130: S106 – S116. doi: 10.1053 / j.gastro.2005.11.049.
  3. Ashkanazi J, Carpertier Y, Michelsen C. Nqaij thiab ntshav amino acids tom qab raug mob. Ann Surg. 1980; 192: 78–85. doi: 10.1097 / 00000658-198007000-00014.