Urolithin B hmoov

Kaum ib hlis 9, 2020

Cofttek yog qhov zoo tshaj plaws Urolithin B hmoov chaw tsim tshuaj paus hauv Suav teb. Peb lub Hoobkas muaj kev ua tiav kev tswj hwm kev tsim khoom (ISO9001 & ISO14001), nrog lub peev xwm tsim khoom txhua hli ntawm 200kg.

 


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 1kg / hnab, 25kg / Nruas

Urolithin BSpecifications

Lub npe: Urolithin IB
Tshuaj Lub Npe: 3-Hydroxy-6H-dibenzo [b, d] pyran-6-ib
CAS: 1139-83-9
Tshuaj Siv Mis: C13H8O3
Molecular phaus: 212.2 g / mol
xim:  Dawb hmoov
Qhov tseem ceeb hauv InChi: WXUQMTRHPNOXBV-UHFFFAOYSA-N
SMILES Txoj Cai: O=C1C2=CC=CC=C2C3=CC=C(O)C=C3O1
Function: Urolithin B tuaj yeem txhim kho mitochondrial thiab cov leeg ua haujlwm.

Urolithin B tuaj yeem txhim kho cov leeg pob txha thiab lub zog thaum lub caij laus.

daim ntawv thov: Urolithin B yog lub plab hnyuv plab zom zaub mov ntawm ellagitannis thiab ua kom pom cov khoom muaj zog tiv thaiv tua hluav taws thiab cov khoom ua kom muaj zog nyob ntawm seb cov kab mob thiab kev ua haujlwm zoo li cas. Urolithin B tseem tuaj yeem tso tawm estrogenic thiab / lossis kev ua haujlwm los tiv thaiv estrogen.
Dej Cev: Yooj yim soluble hauv N, N-dimethylformamide thiab dimethylmethylene. Sulfone, ib nyuag soluble hauv methanol, ethanol, thiab ethyl acetate
Cia Temp: Hygroscopic, -20 ° C Lub Freezer, Nyob rau hauv chaw huab cua
Cov Teeb Meem Them: Shipped hauv ambient kub li tsis muaj tshuaj lom neeg. Cov khoom no ruaj khov txaus rau ob peb lub lis piam thaum cov khoom qub thiab sij hawm siv hauv kev lis kev cai.

 

Urolithin IB NMR Spectrum NPE

Urolithin B (1139-83-9)-NMR Spectrum

 

Yog tias koj xav tau COA, MSDS, HNMR rau txhua qhov khoom seem thiab lwm yam ntaub ntawv, thov hu rau peb tus thawj tswj kev lag luam.

 

Taw qhia rau Urolithins

Urolithins yog cov metabolites theem nrab ntawm ellagic acid muab los ntawm ellagitannins. Hauv tib neeg ellagitannins hloov dua siab tshiab los ntawm lub plab microflora rau hauv ellagic acid uas tau hloov mus rau urolithins A, urolithin B, urolithin C thiab urolithin D hauv cov hnyuv loj.

Urolithin A (UA) yog cov feem ntau ntawm cov metabolite ntawm ellagitannins. Txawm li cas los xij, urolithin A tseem tsis tau paub tias tshwm sim ib txwm muaj hauv tej khoom noj haus twg los.

Urolithin B (UB) yog cov metabolite ntau nyob rau hauv lub plab los ntawm kev hloov pauv ntawm ellagitannins. Urolithin B yog cov khoom kawg tom qab txhua lwm cov urolithin derivatives yog catabolized. Urolithin B yog pom nyob hauv cov zis raws li urolithin B glucuronide.

Urolithin A 8-Methyl Ether yog cov khoom lag luam theem nruab nrab thaum lub sijhawm sib sau ntawm Urolithin A. Nws yog qhov tseem ceeb ntawm cov metabolite ntawm ellagitannin thiab muaj cov khoom ua antioxidant thiab anti-inflammatory.

 

Mechanism ntawm kev ua ntawm urolithin A thiab B

Rol Urolithin A yauv ua kom mob plab zom mov

Mitophagy yog ib daim ntawv ntawm autophagy uas pab tshem tawm mitochondrial rau lawv txoj haujlwm zoo. Autophagy yog hais txog cov txheej txheem dav dav hauv cov ntsiab lus cytoplasmic tau degraded thiab yog li rov ua dua tshiab thaum mitophagy yog qhov kev ua tsis zoo thiab rov ua dua ntawm mitochondria.

Thaum lub caij laus kev txo qis hauv autophagy yog ib qho uas ua rau txo qis hauv kev ua haujlwm ntawm mitochondrial. Ntxiv mus, oxidative kev nyuab siab kuj tseem tuaj yeem ua rau tsis muaj autophagy. Urolithin Ib qho kev muaj peev xwm tshem tawm mitochondria los ntawm kev xaiv autophagy.

Ioxid Antioxidant zog

Oxidative kev nyuaj siab tshwm sim thaum muaj qhov tsis txaus ntawm cov dawb radicals thiab antioxidant hauv lub cev. Cov tshuaj dawb no feem ntau txuam nrog ntau yam mob mob xws li mob plawv, ntshav qab zib thiab mob cancer.

Urolithins A thiab B nthuav tawm cov tshuaj tiv thaiv antioxidant los ntawm lawv lub peev xwm los txo cov dawb radicals thiab tshwj xeeb tshaj tawm cov qib muaj pa oxygen (ROS) thiab kuj cuam tshuam lipid peroxidation hauv qee hom cell.

Ntxiv mus, urolithins muaj peev xwm inhibit qee qhov oxidizing enzymes, suav nrog monoamine oxidase A thiab tyrosinase.

Anti-inflammatory khoom

Kev o yog qhov txheej txheem uas peb lub cev tawm tsam txhua yam uas poob xws li mob, raug mob, thiab microbes. Txawm li cas los xij, mob o tuaj yeem tsim kev puas tsuaj rau lub cev vim tias qhov no cuam tshuam nrog ntau yam kev cuam tshuam xws li mob hawb pob, mob plawv, thiab mob cancer. Tus mob mus ntev yuav tshwm sim vim yog tsis kho tus mob, tus mob kis los yog dawb radicals hauv lub cev.

Urolithins A thiab B ua pov thawj cov khoom tiv thaiv kev tiv thaiv los ntawm kev tiv thaiv nitric oxide ntau lawm. Lawv tshwj xeeb inhibit inducible nitric oxide synthase (iNOS) protein thiab mRNA qhia uas yog lub luag hauj lwm rau o.

Los tiv thaiv microbial cuam tshuam

Cov kab mob microbes suav nrog cov kab mob, cov hu ua fungi thiab viruses tuaj yeem tshwm sim ib puag ncig thiab txawm nyob hauv tib neeg lub cev. Txawm li cas los xij, qee cov kab mob me me uas hu ua cov kab mob yuav ua rau kis mob xws li khaub thuas, qhua pias thiab mob npaws.

Urolithin A thiab B muaj peev xwm nthuav tawm cov tshuaj tua kab mob kev ua haujlwm los ntawm kev ua kom tsis pom kev hauv pawg. Quorum sensing yog ib hom kev sib txuas lus ntawm cov kab mob uas ua rau cov kab mob tuaj yeem kuaj thiab tswj cov kab mob sib kis xws li kev ua siab ntev thiab kev ua kom muaj zog.

● Inhibitioniting protein glycation

Glycation hais txog qhov tsis-enzymatic txuas ntawm qab zib rau ib lipid lossis protein ntau. Nws yog biomarker tseem ceeb hauv ntshav qab zib thiab lwm yam kev cuam tshuam nrog rau kev laus.

Glycation muaj protein ntau yog qhov muaj txiaj ntsig thib ob ntawm hyperglycemia muaj lub luag haujlwm tseem ceeb hauv kev mob plawv ntsig txog ntshav qab zib xws li ntshav qab zib thiab Alzheimer tus kab mob.

Urolithin A thiab B muaj cov khoom tiv thaiv glycative uas yog koob tshuaj uas ywj pheej ntawm lawv cov kev ua haujlwm antioxidant.

 

Cov txiaj ntsig Urolithin B

Urolithin B tshuaj pab tseem muaj ntau lub txiaj ntsim kev noj qab haus huv thiab feem ntau zoo ib yam li cov txiaj ntsig ntawm urolithin A.

(1) Muaj tshuaj los tiv thaiv tus mob qog noj ntshav
Cov khoom siv tiv thaiv urolithin B ua rau nws yog tus neeg sib tw zoo rau kev ntaus mob qog ntshav. Qee cov kws tshawb nrhiav tau tshaj tawm cov peev xwm no hauv cov fibroblasts, microphages thiab endothelial hlwb.

Cov kev tshawb fawb tau tshaj tawm tias UB inhibits ntau hom mob cancer xws li prostate, mob hnyuv thiab zais zis.

Hauv kev tshawb nrhiav txog tib neeg mob hlwb mob hlwb, ellagitannins, ellagic acid thiab urolithins A thiab B tau raug tshuaj xyuas vim lawv cov peev xwm tiv thaiv qog noj ntshav. Lawv tshaj tawm tias txhua txoj kev kho tau tuaj yeem txwv txoj kev loj hlob ntawm cov qog nqaij hlav cancer. Lawv inhibited cov kabmob mob hlwb loj hlob dhau mus los ntawm lub sijhawm kaw ntawm tes ntawm ntau qib thiab tseem los ntawm kev ua kom muaj kabmob apoptosis.

(2) tuaj yeem pab tawm tsam oxidative kev ntxhov siab
Urolithin B muaj cov antioxidant zoo heev los ntawm kev txo cov qib pa oxygen thiab qib lipid peroxidation hauv qee hom cell. Cov qib siab ntawm ROS cuam tshuam nrog ntau yam kev ntshawv siab xws li Alzheimer tus kab mob.

Hauv kev tshawb fawb nrog cov hlwb neuronal raug rau oxidative kev nyuaj siab, urolithin B ntxiv rau urolithin A tau pom los tiv thaiv lub hlwb tiv thaiv oxidation li nce qib kev muaj sia nyob ntawm tes.

(3) Urolithin B hauv kev nco nco zoo
Urolithin b tau tshaj tawm tias txhim kho cov ntshav-thaiv permeability. Qhov no pab txhim kho kev txawj xav.

Cov kev tshawb fawb qhia tias urolithin B tuaj yeem yog lub cim xeeb muaj txiaj ntsig zoo los ntawm kev txhim kho kev paub ntawm kev ua haujlwm dav dav.

(4) Tiv thaiv kev mob leeg
Kev poob cev nqaij hlav tuaj yeem tshwm sim vim ntau yam xws li kev tsis sib haum, kev laus thiab lub cev tsis muaj protein ntau ntawm cov zaub mov noj. Ntau yam kev ntsuas los txwv, txwv lossis zoo dua rau kev tiv thaiv cov leeg mob nrog rau, kev tawm dag zog, tshuaj thiab cov amino acids zoo li polyphenols tuaj yeem ua haujlwm.

Urolithins tuaj yeem muab cais ua cov polyphenols thiab ua lub luag haujlwm hauv kev tiv thaiv cov leeg mob los ntawm kev ua kom cov leeg lub zog ua kom zoo nkauj thiab tseem ua rau muaj kev cuam tshuam qis.

Hauv kev tshawb fawb nrog cov nas, Urolithin B tshuaj muab tshuaj ntxiv rau lub sijhawm ib ntus tau pom los txhim kho lawv cov leeg kev txhim kho thaum cov leeg pom tau tias lawv loj dua.

(5) Urolithin B sib ntaus los tiv thaiv tus mob
Urolithin B muaj cov khoom coj los tiv thaiv los ntawm kev txo cov zas cim ntau ntxiv.

Hauv kev tshawb fawb ntawm cov nas nrog kev xav hauv lub raum plab hlaub, urolithin B tau pom tias yuav ua rau lub raum raug mob. Nws txhim kho lub raum muaj nuj nqi, morphology ntawm lub raum zoo li ntxiv txo lub raum qhov kev raug mob. Qhov no qhia tau tias UB muaj peev xwm txo tau qhov mob raum.

(6) Cov kev pab cuam synergistic ntawm urolithin A thiab B
Synergistic cov teebmeem tseem tau tshaj tawm cov kev sib xyaw ua ke ntawm urolithin A thiab B hauv kev txawj ntse thiab kev muaj peev xwm. Txoj kev tshawb no tau hais tias kev sib xyaw ua ke no tuaj yeem siv rau hauv kev kho lossis tiv thaiv kev mob dementia-cuam tshuam xws li ntxhov siab lossis Alzheimer tsis meej.

Lwm cov txiaj ntsig nrog urolithins yog;

  • neuroprotection
  • Ameliorates metabolic syndrome

 

Urolithin A thiab B cov khoom noj muaj txiaj ntsig

Urolithins tsis paub kom pom los ntawm cov zaub mov qhov twg los. Lawv yog cov khoom lag luam ntawm kev hloov pauv ntawm ellagic acids uas yog los ntawm ellagitannins. Ellagitannins tau hloov pauv mus rau ellagic acids los ntawm lub plab microbiota thiab ellagic acid yog ntxiv hloov mus rau hauv nws cov metabolites (urolithins) hauv cov hnyuv loj.

Ellagitannins tshwm sim ib txwm muaj hauv cov khoom noj muaj txiaj ntsig xws li pomegranates, cov txiv ntoo nrog rau cov txiv pos nphuab, txiv pos, txiv pos nphuab thiab blackberries, txiv quav ntswv nyoos txiv ntoo, almonds, zaub txhwb, tshuaj yej, thiab noob txiv ntoo xws li walnuts thiab txiv ntseej thiab cawv txiv ntoo xws li cawv txiv ntoo liab thiab cawv txiv ntoo los ntawm ntoo qhib tej kas tham.

Peb thiaj li txiav txim siab urolithin A cov zaub mov thiab urolithin B cov zaub mov yog cov khoom noj uas muaj ellagitannin. Nws yog tsim nyog sau cia tias ellagitannin bioavailability muaj tsawg heev thaum nws cov khoom noj ntawm lub cev muaj zog (urolithins) tau yooj yim.

Urolithins kev nthuav dav thiab kev tsim tawm sib txawv ntawm cov tib neeg txij li kev hloov pauv los ntawm ellagitannins cia siab rau microbiota hauv lub plab. Muaj qee cov kab mob tshwj xeeb hauv kev hloov pauv no thiab sib txawv ntawm cov tib neeg uas qee qhov muaj cov siab, qis lossis tsis muaj cov microbiota tsim nyog. Cov zaub mov xa tuaj kuj sib txawv hauv lawv cov qib ellagitannins. Yog li qhov txiaj ntsig zoo ntawm ellagitannins sib txawv ntawm ib tus neeg mus rau lwm tus.

 

Urolithin A thiab B Tshuaj Ntxiv

Urolithin Ib cov tshuaj ntxiv rau Urolithin B tshuaj pab tau yooj yim pom hauv khw muaj ellagitannin-nplua nuj cov khoom noj muaj txiaj ntsig zoo. Urolithin A tshuaj pab cuam kuj tseem muaj nyob hauv. Feem ntau cov tshuaj pomegranates tau dav muag thiab siv nrog kev vam meej. Cov tshuaj noj no tau tsim los ntawm cov txiv hmab txiv ntoo lossis txiv ntoo thiab tsim ua kua lossis hmoov tshuaj.

Vim tias muaj kev hloov pauv hauv ellagitannins concentration hauv cov zaub mov sib txawv, cov neeg muas zaub ntawm urolithin yuav nws tso rau hauv kev xav txog cov khoom noj khoom haus. Tib yam siv rau thaum nrhiav rau urolithin B hmoov lossis kua tshuaj ntxiv.

Qhov tsawg kawg ntawm tib neeg cov kev tshawb fawb soj ntsuam ua nrog urolithin A hmoov lossis B tsis tau tshaj tawm txog kev phiv los ntawm kev tswj hwm ntawm cov tshuaj no.

reference

  1. Garcia-Muñoz, Cristina; Vaillant, Fabrice (2014-12-02). "Metabolic Fate ntawm Ellagitannins: cuam tshuam rau kev noj qab haus huv, thiab Kev Tshawb Fawb Kev Xav rau Cov Khoom Noj Ua Haujlwm Tshiab". Kev Ntsuam Xyuas Tseem Ceeb hauv Zaub Mov Kev Noj Qab Haus Huv thiab Khoom Noj Khoom Haus.
  2. Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 Kaum Ib Hlis 2009). "Urolithins, plab hnyuv microbial metabolites ntawm Pomegranate ellagitannins, nthuav tawm cov tshuaj tiv thaiv kab mob muaj zog hauv kev ntsuas ntawm tes". J Agric Food Chem.
  3. Bodwell, Graham; Pottie, Ian; Nandaluru, Penchal (2011). "Ib qho kev hloov pauv hluav taws xob-xav tau Diels-Alder-Raws Li Tag Nrho Cov Synthesis ntawm Urolithin M7".