Urolithin Ib hmoov

Kaum ib hlis 9, 2020

Cofttek yog qhov zoo tshaj plaws Urolithin A hmoov chaw tsim tshuaj paus hauv Suav teb. Peb lub Hoobkas muaj kev ua tiav kev tswj hwm kev tsim khoom (ISO9001 & ISO14001), nrog lub peev xwm tsim khoom txhua hli ntawm 400kg.

 


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 1kg / hnab, 25kg / Nruas

Urolithin Ib Cov Hmoov Tshwj Xeeb

Lub npe: Urolithin A.
Tshuaj Lub Npe: 3,8-Dihydroxybenzo [c] chromen-6-ib
CAS: 1143-70-0
Tshuaj Siv Mis: C13H8O4
Molecular phaus: 228.2
xim: Dawb rau hmoov av dawb
Qhov tseem ceeb hauv InChi: RIUPLDUFZCXCHM-UHFFFAOYSA-N
SMILES Txoj Cai: O=C1C2=CC(O)=CC=C2C3=C(O1)C=C(O)C=C3
Function: Urolithin A, lub plab-microbial metabolite ntawm ellagic acid, siv tshuaj tiv thaiv, tiv thaiv antiproliferative, thiab lub zog tiv thaiv lub zog. Urolithin A induces autophagy thiab apoptosis, txhawb kev muaj kev voj voog ntawm tes, thiab inhibits DNA synthesis.
daim ntawv thov: Urolithin A yog tshuaj metabolite ntawm ellagitannin; Kws Tshuaj Intermediates
Dej Cev: Soluble hauv DMSO (3 mg / mL).
Cia Temp: Qhuav, tsaus thiab nyob rau hauv 0 - 4 C rau lub sij hawm luv (hnub mus rau lub lis piam) lossis -20 C rau lub sij hawm ntev (hli txog xyoo).
Cov Teeb Meem Them: Shipped hauv ambient kub li tsis muaj tshuaj lom neeg. Cov khoom no ruaj khov txaus rau ob peb lub lis piam thaum cov khoom qub thiab sij hawm siv hauv kev lis kev cai.

 

Urolithin A. NMR Spectrum NPE

Urolithin A (1143-70-0)-NMR Spectrum

Yog tias koj xav tau COA, MSDS, HNMR rau txhua qhov khoom seem thiab lwm yam ntaub ntawv, thov hu rau peb tus thawj tswj kev lag luam.

 

Taw qhia rau Urolithins

Urolithins yog cov metabolites theem nrab ntawm ellagic acid muab los ntawm ellagitannins. Hauv tib neeg ellagitannins hloov dua siab tshiab los ntawm lub plab microflora rau hauv ellagic acid uas tau hloov mus rau urolithins A, urolithin B, urolithin C thiab urolithin D hauv cov hnyuv loj.

Urolithin A (UA) yog cov feem ntau ntawm cov metabolite ntawm ellagitannins. Txawm li cas los xij, urolithin A tseem tsis tau paub tias tshwm sim ib txwm muaj hauv tej khoom noj haus twg los.

Urolithin B (UB) yog cov metabolite ntau nyob rau hauv lub plab los ntawm kev hloov pauv ntawm ellagitannins. Urolithin B yog cov khoom kawg tom qab txhua lwm cov urolithin derivatives yog catabolized. Urolithin B yog pom nyob hauv cov zis raws li urolithin B glucuronide.

Urolithin A 8-Methyl Ether yog cov khoom lag luam theem nruab nrab thaum lub sijhawm sib sau ntawm Urolithin A. Nws yog qhov tseem ceeb ntawm cov metabolite ntawm ellagitannin thiab muaj cov khoom ua antioxidant thiab anti-inflammatory.

 

Mechanism ntawm kev ua ntawm urolithin A thiab B

Rol Urolithin A yauv ua kom mob plab zom mov

Mitophagy yog ib daim ntawv ntawm autophagy uas pab tshem tawm mitochondrial rau lawv txoj haujlwm zoo. Autophagy yog hais txog cov txheej txheem dav dav hauv cov ntsiab lus cytoplasmic tau degraded thiab yog li rov ua dua tshiab thaum mitophagy yog qhov kev ua tsis zoo thiab rov ua dua ntawm mitochondria.

Thaum lub caij laus kev txo qis hauv autophagy yog ib qho uas ua rau txo qis hauv kev ua haujlwm ntawm mitochondrial. Ntxiv mus, oxidative kev nyuab siab kuj tseem tuaj yeem ua rau tsis muaj autophagy. Urolithin Ib qho kev muaj peev xwm tshem tawm mitochondria los ntawm kev xaiv autophagy.

Ioxid Antioxidant zog

Oxidative kev nyuaj siab tshwm sim thaum muaj qhov tsis txaus ntawm cov dawb radicals thiab antioxidant hauv lub cev. Cov tshuaj dawb no feem ntau txuam nrog ntau yam mob mob xws li mob plawv, ntshav qab zib thiab mob cancer.

Urolithins A thiab B nthuav tawm cov tshuaj tiv thaiv antioxidant los ntawm lawv lub peev xwm los txo cov dawb radicals thiab tshwj xeeb tshaj tawm cov qib muaj pa oxygen (ROS) thiab kuj cuam tshuam lipid peroxidation hauv qee hom cell.

Ntxiv mus, urolithins muaj peev xwm inhibit qee qhov oxidizing enzymes, suav nrog monoamine oxidase A thiab tyrosinase.

Anti-inflammatory khoom

Kev o yog qhov txheej txheem uas peb lub cev tawm tsam txhua yam uas poob xws li mob, raug mob, thiab microbes. Txawm li cas los xij, mob o tuaj yeem tsim kev puas tsuaj rau lub cev vim tias qhov no cuam tshuam nrog ntau yam kev cuam tshuam xws li mob hawb pob, mob plawv, thiab mob cancer. Tus mob mus ntev yuav tshwm sim vim yog tsis kho tus mob, tus mob kis los yog dawb radicals hauv lub cev.

Urolithins A thiab B ua pov thawj cov khoom tiv thaiv kev tiv thaiv los ntawm kev tiv thaiv nitric oxide ntau lawm. Lawv tshwj xeeb inhibit inducible nitric oxide synthase (iNOS) protein thiab mRNA qhia uas yog lub luag hauj lwm rau o.

Los tiv thaiv microbial cuam tshuam

Cov kab mob microbes suav nrog cov kab mob, cov hu ua fungi thiab viruses tuaj yeem tshwm sim ib puag ncig thiab txawm nyob hauv tib neeg lub cev. Txawm li cas los xij, qee cov kab mob me me uas hu ua cov kab mob yuav ua rau kis mob xws li khaub thuas, qhua pias thiab mob npaws.

Urolithin A thiab B muaj peev xwm nthuav tawm cov tshuaj tua kab mob kev ua haujlwm los ntawm kev ua kom tsis pom kev hauv pawg. Quorum sensing yog ib hom kev sib txuas lus ntawm cov kab mob uas ua rau cov kab mob tuaj yeem kuaj thiab tswj cov kab mob sib kis xws li kev ua siab ntev thiab kev ua kom muaj zog.

● Inhibitioniting protein glycation

Glycation hais txog qhov tsis-enzymatic txuas ntawm qab zib rau ib lipid lossis protein ntau. Nws yog biomarker tseem ceeb hauv ntshav qab zib thiab lwm yam kev cuam tshuam nrog rau kev laus.

Glycation muaj protein ntau yog qhov muaj txiaj ntsig thib ob ntawm hyperglycemia muaj lub luag haujlwm tseem ceeb hauv kev mob plawv ntsig txog ntshav qab zib xws li ntshav qab zib thiab Alzheimer tus kab mob.

Urolithin A thiab B muaj cov khoom tiv thaiv glycative uas yog koob tshuaj uas ywj pheej ntawm lawv cov kev ua haujlwm antioxidant.

 

Urolithin Cov txiaj ntsig

(1) tuaj yeem rub tawm kom muaj sia ntev dua
Urolithin A induces mitophagy los ntawm kev xaiv tshem tawm cov mitochondria. Qhov no tseem ua kom muaj qhov rov ua dua ntawm mitochondria rau kev ua haujlwm zoo. Mitochondria feem ntau tau txais kev puas tsuaj nrog lub hnub nyoog thiab tseem vim muaj kev ntxhov siab. Kev rhuav tshem ntawm mitochondria ua si lub luag haujlwm hauv kev txuas ntxiv lub neej.

Hauv kev kawm txog cov cua nab, urolithin Ib qho tshuaj ntxiv muab rau 50 µM los ntawm lub qe theem txog kev tuag tau pom tias txuas lawv lub neej txog li 45.4%.

Hauv lwm qhov kev tshawb nrhiav hauv 2019 siv cov laus ntawm tib neeg fibroblasts, urolithin Ib qho ntxiv tau pom tias muaj pov thawj tawm tsam kev laus. Nws tau muaj peev xwm nce ntxiv hom 1 collagen qhia thiab kuj txo qhov kev qhia ntawm matrix metalloproteinase 1.

Kev tshawb nrhiav tib neeg me tseem qhia tau tias UA tau tuaj yeem txhim kho mitochondrial muaj nuj nqi thiab pob txha huv rau cov neeg laus thaum muab qhov ncauj ntawm 500-1000mg rau ib lub sijhawm plaub lub lis piam.

(2) Pab tiv thaiv tus mob prostate
Cov urolithins thiab lawv ua ntej, ellagitannins, muaj cov khoom los tiv thaiv tus mob cancer. Lawv muaj peev xwm inhibit cancer-cell proliferation los ntawm kev voj voog ntawm tes raug ntes thiab ntxias cov apoptosis. Apoptosis yog hais txog kev tuag ntawm tes uas ua rau lub cev tshem tawm cov kev mob qog nqaij hlav cancer thiab lwm cov qe ntshav muaj mob.

Hauv kev kawm txog cov nas txhaj nrog tib neeg mob qog noj ntshav, ellagitannins metabolites (Urolithin A) tau pom tias inhibit kev loj hlob ntawm prostate cancer. Txoj kev tshawb nrhiav ntxiv qhia ntau dua cov concentration metabolites hauv lub prostate caj pas, cov hnyuv thiab cov hnyuv.

(3) Kev txhim kho kev txawj ntse
Urolithin A muaj peev xwm tiv thaiv neurons los ntawm kev tuag thiab tseem tuaj yeem ua rau neurogenesis los ntawm kev tiv thaiv kev tiv thaiv.

Hauv kev kawm txog cov nas uas muaj qhov cim xeeb tsis zoo, urolithin A tau pom tias ameliorate lub hlwb puas tsuaj thiab tiv thaiv neurons los ntawm apoptosis. Qhov no qhia tau tias UA tuaj yeem siv rau hauv kev kho mob Alzheimer tus kab mob (AD).

(4) Los tiv thaiv kev rog muaj peev xwm
Kev tshawb fawb qhia tau tias ellagitannins muaj peev xwm inhibit lipid txuam nrog thiab kuj muaj adipogenic cov cim xws li kev loj hlob teb thaum ntxov protein 2 nrog rau kev txhim kho-khi hauv cov protein los ntawm kev kaw lub voj voog.

Urolithin A tau pom tshwj xeeb los txhim kho cov tshuaj insulin rhiab li tiv thaiv kev txhim kho kev rog.

Hauv kev tshawb fawb ntawm cov nas nrog kev rog vim kev rog, urolithin Ib qho kev pom ntxiv tau pom los tiv thaiv kev rog kev rog thiab kev cuam tshuam ntawm cov rog hauv cov nas. Txoj kev tshawb no pom tias kev kho mob UA ntxiv kev siv hluav taws xob ntau dua li cov kev coj ua lub cev qis.

 

Urolithin A thiab B cov khoom noj muaj txiaj ntsig

Urolithins tsis paub kom pom los ntawm cov zaub mov qhov twg los. Lawv yog cov khoom lag luam ntawm kev hloov pauv ntawm ellagic acids uas yog los ntawm ellagitannins. Ellagitannins tau hloov pauv mus rau ellagic acids los ntawm lub plab microbiota thiab ellagic acid yog ntxiv hloov mus rau hauv nws cov metabolites (urolithins) hauv cov hnyuv loj.

Ellagitannins tshwm sim ib txwm muaj hauv cov khoom noj muaj txiaj ntsig xws li pomegranates, cov txiv ntoo nrog rau cov txiv pos nphuab, txiv pos, txiv pos nphuab thiab blackberries, txiv quav ntswv nyoos txiv ntoo, almonds, zaub txhwb, tshuaj yej, thiab noob txiv ntoo xws li walnuts thiab txiv ntseej thiab cawv txiv ntoo xws li cawv txiv ntoo liab thiab cawv txiv ntoo los ntawm ntoo qhib tej kas tham.

Peb thiaj li txiav txim siab urolithin A cov zaub mov thiab urolithin B cov zaub mov yog cov khoom noj uas muaj ellagitannin. Nws yog tsim nyog sau cia tias ellagitannin bioavailability muaj tsawg heev thaum nws cov khoom noj ntawm lub cev muaj zog (urolithins) tau yooj yim.

Urolithins kev nthuav dav thiab kev tsim tawm sib txawv ntawm cov tib neeg txij li kev hloov pauv los ntawm ellagitannins cia siab rau microbiota hauv lub plab. Muaj qee cov kab mob tshwj xeeb hauv kev hloov pauv no thiab sib txawv ntawm cov tib neeg uas qee qhov muaj cov siab, qis lossis tsis muaj cov microbiota tsim nyog. Cov zaub mov xa tuaj kuj sib txawv hauv lawv cov qib ellagitannins. Yog li qhov txiaj ntsig zoo ntawm ellagitannins sib txawv ntawm ib tus neeg mus rau lwm tus.

 

Urolithin A thiab B Tshuaj Ntxiv

Urolithin Ib cov tshuaj ntxiv rau Urolithin B tshuaj pab tau yooj yim pom hauv khw muaj ellagitannin-nplua nuj cov khoom noj muaj txiaj ntsig zoo. Urolithin A tshuaj pab cuam kuj tseem muaj nyob hauv. Feem ntau cov tshuaj pomegranates tau dav muag thiab siv nrog kev vam meej. Cov tshuaj noj no tau tsim los ntawm cov txiv hmab txiv ntoo lossis txiv ntoo thiab tsim ua kua lossis hmoov tshuaj.

Vim tias muaj kev hloov pauv hauv ellagitannins concentration hauv cov zaub mov sib txawv, cov neeg muas zaub ntawm urolithin yuav nws tso rau hauv kev xav txog cov khoom noj khoom haus. Tib yam siv rau thaum nrhiav rau urolithin B hmoov lossis kua tshuaj ntxiv.

Qhov tsawg kawg ntawm tib neeg cov kev tshawb fawb soj ntsuam ua nrog urolithin A hmoov lossis B tsis tau tshaj tawm txog kev phiv los ntawm kev tswj hwm ntawm cov tshuaj no.

reference

  1. Garcia-Muñoz, Cristina; Vaillant, Fabrice (2014-12-02). "Metabolic Fate ntawm Ellagitannins: cuam tshuam rau kev noj qab haus huv, thiab Kev Tshawb Fawb Kev Xav rau Cov Khoom Noj Ua Haujlwm Tshiab". Kev Ntsuam Xyuas Tseem Ceeb hauv Zaub Mov Kev Noj Qab Haus Huv thiab Khoom Noj Khoom Haus.
  2. Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 Kaum Ib Hlis 2009). "Urolithins, plab hnyuv microbial metabolites ntawm Pomegranate ellagitannins, nthuav tawm cov tshuaj tiv thaiv kab mob muaj zog hauv kev ntsuas ntawm tes". J Agric Food Chem.
  3. Bodwell, Graham; Pottie, Ian; Nandaluru, Penchal (2011). "Ib qho kev hloov pauv hluav taws xob-xav tau Diels-Alder-Raws Li Tag Nrho Cov Synthesis ntawm Urolithin M7".