Qhov zoo tshaj plaws Pyridoxal hydrochloride hmoov Chaw tsim tshuaj paus

Pyridoxal hydrochloride (65-22-5)

Tej zaum 11, 2021

Cofttek yog qhov zoo tshaj Pyridoxal hydrochloride hmoov chaw tsim tshuaj paus hauv Suav teb. Peb lub Hoobkas tau ua tiav kev tswj hwm kev tsim khoom (ISO9001 & ISO14001), nrog lub peev xwm tsim khoom txhua hli ntawm 320kg.

 


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 1kg / hnab, 25kg / Nruas

Pyridoxal hydrochloride (65-22-5) Specifications

Lub npe: Pyridoxal hydrochloride
CAS: 65-22-5
purity 98%
Cov mis qauv: C8H10ClNO3
Lub cev nyhav: 203.622 g / mol
Melt Point: 173 ° C
Tshuaj lub npe: PYRIDOXAL HYDROCHLORIDE

Pyridoxal HCl 3-Hydroxy-5- (hydroxymethyl) -2-methylisonicotinaldehyde hydrochloride

txhais: 3-hydroxy-5- (hydroxymethyl) -2-methyl-4-pyridinecarboxaldehyde hydrochloride / Pyridoxal HCl
Qhov tseem ceeb hauv InChI: FCHXJFJNDJXENQ-UHFFFAOYSA-N
Ib nrab neej: N / A
Dej Cev: Soluble hauv dej
Cia Kev Mob: 0 - 4 C rau lub sij hawm luv (hnub rau lis piam), lossis -20 C rau lub sij hawm ntev (hli)
daim ntawv thov: Nws yog qhov tsim nyog los tswj kev noj qab haus huv ntawm cov hlab ntsha, tawv nqaij, thiab ntshav liab. Pyridoxine tau siv los tiv thaiv lossis kho qee yam mob puas hlwb (peripheral neuropathy) tshwm sim los ntawm qee yam tshuaj noj (xws li isoniazid).
tsos: Dawb ntawm off-dawb hmoov

 

Pyridoxal hydrochloride (65-22-5) NMR Spectrum NPE

Pyridoxal hydrochloride (65-22-5)

Yog tias koj xav tau COA, MSDS, HNMR rau txhua qhov khoom seem thiab lwm yam ntaub ntawv, thov hu rau peb tus thawj tswj kev lag luam.

 

Pyridoxal Hydrochloride yog dab tsi?

Pyridoxal hydrochloride yog ib hom vitamin B6. Raws li 4-carbaldehyde daim ntawv ntawm cov vitamin B6, nws yog ua los ntawm kev sib xyaw pyridoxal nrog ib tus hniav sib npaug ntawm hydrochloric acid. Nws yog khoom noj haus ntxiv. Nws cov tshuaj lom yog C8H10ClNO3. Nws lub npe IUPAC yog 3-hydroxy-5- (hydroxymethyl) -2-methyl pyridine-4-carbaldehyde hydrochloride.

Cov tshuaj no yog cov chav kawm organic hu ua pyridoxal thiab nws cov txiaj ntsig. Cov no muaj cov pyridoxal moiety nrog lub nplhaib pyridine muaj kev hloov pauv ntawm ntau cov ntsiab lus. Cov ntsiab lus hloov pauv no suav nrog pab pawg methyl hauv txoj haujlwm 2, pawg hydroxyl hauv txoj haujlwm 3, pawg carbaldehyde hauv txoj haujlwm 4, thiab pawg hydroxymethyl hauv txoj haujlwm 5.

Pyridoxal hydrochloride yog siv hauv kev kho mob ntshav qab zib nephropathy. Nws xav tau los tswj kev noj qab haus huv ntawm qab haus huv, tawv nqaij, thiab cov qe ntshav liab. Nws tau siv los ntawm lub cev los ua cov tshuaj xa xov zoo li serotonin thiab norepinephrine. Nws kuj tseem pab ua kom sphingolipids thiab aminolevulinic acid. Pyridoxal hydrochloride tau hloov pauv mus rau pyridoxal 5-phosphate, coenzyme rau kev sib txuas cov amino acids.

Txij li thaum vitamin B6 tsis tuaj yeem tsim los ntawm lub cev nws yuav tsum tau siv los ntawm ntau qhov chaw lossis los ntawm cov tshuaj ntxiv. Nws tshwm sim hauv ntau hom ntawv ib ntawm lawv yog pyridoxal uas yog 4-carboxaldehyde daim ntawv ntawm vitamin B6 thiab tseem yog cofactor rau ntau yam kev ua ub no.

Pyridoxal hydrochloride yog ntsev ntsev ntawm pyridoxal thiab npaj tau hloov pauv hauv pyridoxal phosphate uas tseem hu ua PLP tom qab kev tswj hwm thiab ua haujlwm ua coenzyme rau kev ua haujlwm metabolic.

 

Pyridoxal Hydrochloride Ua Haujlwm Li Cas?

Vitamin B6 muaj peb yam xwm txheej: pyridoxine, pyridoxal, thiab pyridoxamine, txhua yam uas hloov pauv mus rau hauv lawv daim ntawv nquag siv hauv lub cev thiab hu ua pyridoxal 5'-phosphate. Cov tsos mob ntawm cov vitamin B6 tsis txaus yog seborrheic dermatitis, microcytic anemia, glossitis, convulsions, peripheral neuropathy, kev nyuaj siab, thiab lwm yam. Vitamin B6 kuj tseem yuav kho isoniazid overdose, tsis raug ntxiv cov nceb lom, raug hydrazine, thiab lwm yam Pyridoxal hydrochloride tuaj yeem ua raws li ntxiv txhawm rau ntxiv cov vitamin B6 hauv lub cev.

Pyridoxal hydrochloride yog ib qho ua ntej ntawm pyridoxal 5'- phosphate. Tom qab siv pyridoxal hydrochloride, nws tau hloov pauv mus rau pyridoxal 5-phosphate hauv hepatocytes thiab cov qog ua kua ntawm cov hnyuv. Tom qab ntawd nws tau nqus los ntawm cov ntshav thiab faib thoob plaws lub cev. Nws koom nrog ntau yam kev cuam tshuam ntawm cov metabolism. Qhov no suav nrog kev tsim thiab cov metabolism ntawm cov amino acids thiab glycogen. Nws kuj tseem tuaj yeem pab ua kom sib txuas cov kab mob nucleic acids, hemoglobin, thiab cov kab mob sib kis.

Pyridoxal 5'-phosphate yog coenzyme koom nrog hauv cov amino acid metabolism. Nws coj zoo li coenzyme hauv txhua qhov kev hloov pauv. Nws kuj tseem koom nrog hauv oxidation thiab deamination cov tshuaj tiv thaiv ntawm cov amino acids.

Pab pawg aldehyde tam sim no hauv pyridoxal 5'-phosphate tsim Schiff-base txuas nrog epsilon-amino pawg ntawm ib pawg lysine tshwj xeeb ntawm aminotransferase enzymes. Cov pab pawg alpha-amino ntawm cov amino acid substrate tom qab ntawd tshem tawm pawg epsilon-amino. Qhov no ua rau tsim cov adimine, uas tau txais deprotonated. Tom qab qhov no, nws dhau los ua quinoid nruab nrab uas lees txais protons ntawm cov haujlwm sib txawv thiab thaum kawg dhau los ua ketimine. Ketimine tom qab ntawd tau txais hydrolyzed kom cov amino pawg tseem nyob ntawm cov protein ntau.

Pyridoxal hydrochloride kuj tseem pab ua kom sib txuas cov neurotransmitters xws li serotonin, dopamine, norepinephrine, thiab gamma-aminobutyric acid.

Pyridoxal hydrochloride tseem tsis tau pom zoo siv los ntawm FDA ເທື່ອ.

 

synthesis

Pyridoxal hydrochloride tau muab coj los ua ke los ntawm cov tshuaj tiv thaiv kab mob los ntawm kev cuam tshuam nrog pyridoxamine nrog ib qho molar ntawm hydrochloric acid. Pyridoxal hydrochloride kuj tseem tuaj yeem ua ke los ntawm kev xaiv oxidation. Cov tshuaj tiv thaiv suav nrog kev noj pyridoxine hydrochloride ua cov khoom pib thiab txheej txheem ntawm catalytic oxidation yuav raug nqa tawm hauv dej. Cov catalytic oxidation suav nrog cov pa oxygen, catalyst, ntsev inorganic, thiab amine ligand. Qhov kawg khoom ntawm catalytic oxidation yuav yog pyridoxal hydrochloride.

 

Pharmacokinetics ntawm Pyridoxal Hydrochloride

Nqa Hose: Lawv tau nqus tau yooj yim los ntawm kev sib kis tsis sib xws thiab lawv nqus tau feem ntau nyob hauv cov hnyuv mucosal uas muaj cov nplua nuj nyob hauv pyridoxine kinase thiab pyridoxal phosphate.

 

Kev lom zem hauv lub cev: Feem ntau ntawm cov organic sib txuas no tau noj los ntawm daim siab thiab qhov ua kom tau txais yog ua los ntawm cov neeg nqa khoom nruab nrab kev sib kis thiab cov txheej txheem zom zaub mov raws li phosphate compounds. Cov phosphorylation ntawm cov sib txuas tau tshwm sim hauv lub siab.

 

faib: Dawb pyridoxal phosphate hauv lub siab yog hydrolyzed rau pyridoxal, uas tom qab xa tawm thiab khi rau hemoglobin thiab albumin hauv erythrocytes. Ib feem dephosphorylated tawm ntawm lub cell los ntawm kev sib kis thiab vim li no yuav muaj kev txuam me me ntawm pyridoxal phosphate hauv cov ntaub so ntswg.

 

Kev zam: Dawb pyridoxal tshuav hauv lub siab tau nrawm oxidized rau 4-pyridoxic acid thiab nws yog cov khoom tseem ceeb ntawm cov khoom sib xyaw. Oxidation rau 4-pyridoxic acid yog kho los ntawm aldehyde dehydrogenase, uas tau nthuav dav nyob hauv ntau cov ntaub so ntswg, oxidation kuj tseem ua los ntawm lub raum thiab hepatic aldehyde oxidase enzymes. Txoj hauv kev tseem ceeb ntawm kev tshem tawm ntawm pyridoxal hydrochloride tom qab cov metabolism yog los ntawm cov zis.

 

Cov txiaj ntsig ntawm Pyridoxal Hydrochloride

Muaj ntau qhov kev siv rau pyridoxal hydrochloride. Txawm li cas los xij, feem ntau ntawm cov kev siv no tseem tab tom tshawb fawb thiab tsis tuaj yeem txiav txim siab siv qhov tseeb rau qhov sib xyaw no.

Nov yog qee qhov txiaj ntsig ntawm pyridoxal hydrochloride

 

Kev cuam tshuam rau Ntshav Qab Zib Nephropathy

Pyridoxal hydrochloride's resultant product pyridoxal 5'-phosphate tuaj yeem tiv thaiv kev tsim cov khoom lag luam glycation kawg (AGEs). Nws ua qhov no los ntawm cuab 3-deoxyglucosone. Hauv kev tshawb fawb nrog cov nas mob ntshav qab zib streptozotocin, lawv tau kho nrog pyridoxal 5-phosphate rau 16 lub lis piam [1]. Cov txiaj ntsig tau pom qhov txo qis hauv albuminuria, glomerular hypertrophy, mesangial nthuav dav, thiab interstitial fibrosis. Nws kuj tseem txo qib AGEs. Li no, nyob ntev, pyridoxal hydrochloride tuaj yeem txo qis nephropathy uas tshwm sim hauv ntshav qab zib.

 

Cov nyhuv ua Metabolite

Pyridoxal hydrochloride thiab pyrimidine 5'-phosphate ua raws li cov tshuaj tseem ceeb xav tau thaum lub sijhawm cov txheej txheem metabolic. Lawv lub peev xwm los ua coenzyme xav tau los ntawm tib neeg lub cev nrog rau ntau yam kab mob thiab kab mob xws li Escherichia coli, Saccharomyces cerevisiae, nas. Lawv tsim nyog los tsim ntau yam sib xyaw xav tau hauv lub cev.

 

Cov nyhuv ntawm Neurotransmitters

Pyridoxal hydrochloride tuaj yeem pab ua ntau yam kev xa xov paj hlwb hauv lub cev.

 

Cov teebmeem ntawm Anemia

Hauv qee qhov anemias, vitamin B6 yog qhov tsim nyog los muab ua ntxiv. Pyridoxal hydrochloride tuaj yeem pab muab qhov tsim nyog pyridoxal 5'-phosphate los kho cov xwm txheej no.

 

Siv hauv Kev Tshawb Fawb Kev Kho Mob

Pyridoxal 5'-phosphate, qhov sib xyaw ua ke ntawm pyridoxal hydrochloride, yog qhov tsim nyog rau qee cov kab mob cuam tshuam txog kev kho mob. Nws yog los xyuas kom lawv txoj kev loj hlob zoo. Nws suav nrog cov kab mob xws li Granulicatella thiab Abiotrophia [2]. Kev noj zaub mov xav tau ntawm pyridoxal hydrochloride tuaj yeem ua rau muaj kab lis kev cai tshwm sim ntawm kev loj hlob ntawm lub hnub qub hauv cov kab mob no. Hauv vitro kab lis kev cai, cov kab mob no tuaj yeem loj hlob tsuas yog hauv qhov chaw uas muaj lwm cov kab mob pyridoxal tsim. Ib qho ntawm cov ntsiab lus tseem ceeb hais txog pyridoxal compound yog tias nws yuav tau hloov zuj zus raws li qhov qub tshaj plaws aerobic cov tshuaj metabolism hauv lub ntiaj teb.

 

Cov Teeb Meem Ntawm Pyridoxal Hydrochloride

  • Cov tawv nqaij voos
  • Kev ua haujlwm tsis zoo
  • Ua pa ua pa
  • xeev siab
  • Ntuav
  • peripheral neuropathy
  • Ua tsis taus lawm
  • Mob taub hau
  • Tsis siab
  • Tingling
  • Lub plab chim siab

 

Kev cuam tshuam ntawm Pyridoxal Hydrochloride Nrog Lwm Yam Tshuaj

Tsis muaj cov ntaub ntawv txaus txog pyridoxal hydrochloride kev cuam tshuam ncaj qha nrog lwm cov tshuaj. Txawm li cas los xij, muaj cov ntaub ntawv paub txog nws cov txiaj ntsig sib xyaw pyridoxal 5'-phosphate kev cuam tshuam nrog lwm cov tshuaj.

Qee qhov kev sib cuam tshuam no yog:

Amiodarone hmoov -Ntawm kev cuam tshuam nrog pyridoxine 5'-phosphate, nws tuaj yeem ua rau rhiab heev rau lub teeb, ua rau tshav ntuj, thiab lwm yam.

Phenytoin -Pyridoxine 5'-phosphate tuaj yeem ua rau cov metabolism hauv ntawm phenytoin hauv lub cev, ua rau muaj txiaj ntsig tsawg dua ntawm qhov kawg.

Phenobarbital -Pyridoxine 5'-phosphate tuaj yeem ua rau lub sijhawm tawg ntawm phenobarbital.

Levodopa - Nws yuav ua rau cov metabolism sai ntawm levodopa.

Thaum tsis muaj pyridoxine paub tias tshwm sim thaum cev xeeb tub thiab pub niam mis, tsis muaj cov ntaub ntawv hais txog qhov cuam tshuam ntawm pyridoxal hydrochloride hauv cov xwm txheej no. Yog li ntawd, nws raug nquahu kom ceev faj.

 

Qhov Yuav Yuav Pyridoxal Hydrochloride nyob rau xyoo 2021?

Koj tuaj yeem yuav pyridoxal hydrochloride hmoov ncaj qha los ntawm lub tuam txhab tsim khoom pyridoxal hydrochloride. Nws muaj nyob hauv tus nqi ntawm 1kg rau ib lub hnab lossis 15kg rau ib lub nruas. Txawm li cas los xij, qhov no tuaj yeem hloov kho raws li qhov xav tau ntawm tus neeg siv. Cov hmoov no yuav tsum tau khaws cia ntawm qhov kub ntawm 0 txog 4 ° rau lub sijhawm luv thiab hauv -20 ° C rau lub sijhawm ntev.

Pyridoxal hydrochloride hmoov muaj nyob hauv daim ntawv dawb lossis xim dawb-dawb. Nws tau ua nrog cov khoom xyaw zoo tshaj plaws hauv kev saib xyuas nruj kom ntseeg tau tias cov neeg siv tau txais cov khoom lag luam zoo tshaj plaws.

 

References

  1. Nakamura, S., Li, H., Adijiang, A., Pischetsrieder, M., & Niwa, T. (2007). Pyridoxal phosphate tiv thaiv kev mob ntshav qab zib nephropathy. Nephrology Dialysis Hloov, 22(8), 2165-2174.
  2. Kitada, K., Okada, Y., Kanamoto, T., & Inoue, M. (2000). Cov khoom muaj txiaj ntsig ntawm Abiotrophia thiab hom Granulicatella (cov khoom noj muaj txiaj ntsig sib txawv streptococci). Microbiology thiab immunology, 44(12), 981-985.

 


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