Qhov zoo tshaj plaws N-Acetyl-L-cysteine ​​ethyl ester (NACET) Chaw Tsim Tshuaj - Cofttek

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

Tej zaum 8, 2021

Cofttek yog qhov zoo tshaj N-Acetyl-L-cysteine ​​ethyl ester (NACET) hmoov chaw tsim tshuaj paus hauv Suav teb. Peb lub Hoobkas muaj kev ua tiav kev tswj hwm kev tsim khoom (ISO9001 & ISO14001), nrog lub peev xwm tsim khoom txhua hli ntawm 300kg.


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 1kg / hnab, 25kg / Nruas

N-Acetyl-L-cysteine ​​ethyl ester (59587-09-6) Specifications

Lub npe: N-Acetyl-L-cysteine ​​ethyl ester (NACET)
CAS: 59587-09-6
purity 98%
Cov mis qauv: C7H13NO3S
Lub cev nyhav: 191.25 g / mol
Melt Point: 197 rau 202 ° C
Tshuaj lub npe: N-Acetyl-L-cysteine ​​ethyl ester

NACET (R) -ethyl 2-acetamido-3-mercaptopropanoate

txhais: N-Acetylcysteine ​​tus cwj pwm; (R) -Methyl 2-acetaMido-3-Mercaptopropanoate; -Ethyl 2-acetamido-3-mercaptopropanoate; Ethyl (2R) -2-Acetamido-3-Sulfanyl-Propanoate; (2R) -2-Acetamido-3-Mercaptopropanoic Acid Ethyl Ester; (2R) -2-Acetamido-3-Mercapto-Propionic Acid Ethyl Ester
Qhov tseem ceeb hauv InChI: MSMRAGNKRYVTCX-LURJTMIESA-N
Ib nrab neej: N / A
Dej Cev: Soluble nyob rau hauv dej
Cia Kev Mob: 0 - 4 C rau lub sij hawm luv (hnub rau lis piam), lossis -20 C rau lub sij hawm ntev (hli)
daim ntawv thov: N-Acetyl-L-cysteine ​​ethyl ester hmoov siv los ua kom lub zog nco, tsom, muaj tswv yim, txawj ntse thiab lub zog.
tsos: Tshem tawm dawb

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) NMR Spectrum NPE

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) NMR Spectrum

Yog tias koj xav tau COA, MSDS, HNMR rau txhua qhov khoom seem thiab lwm yam ntaub ntawv, thov hu rau peb tus thawj tswj kev lag luam.

 

N-Acetyl-L-cysteine ​​ethyl ester yog dab tsi (NACET) (59587-09-6)?

N-Acetyl-L-cysteine ​​ethyl ester hmoov yog lub ntuj lossis cov khoom siv hluavtaws uas tuaj yeem txhim kho lub hlwb ua haujlwm, txhim kho kev xav hauv cov neeg noj qab nyob zoo. Feem ntau hu ua Nootropics thiab cov tshuaj ntse, lawv tau muaj koob meej hauv zej zog cov kev sib tw niaj hnub no thiab feem ntau siv los txhawb kev nco, tsom, muaj tswv yim, txawj ntse thiab kev mob siab.

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) cov txiaj ntsig

Cov tshuaj esterification ntawm pab pawg carboxyl los tsim N-acetylcysteine ​​ethyl ester nce lipophilicity ntawm NAC thiab zoo heev txhim kho nws cov chaw muag tshuaj. NACET muaj ntau dua cov kev nyab xeeb (ncig 60%) dua NAC. NACET sai nkag mus rau hauv lub hlwb, tom qab ntawd nws tab cuab, thiab hloov mus rau hauv NAC thiab Cysteine. NACET yog pom nyob hauv cov kab mob ntawm cov nqaij sib txawv, nrog rau lub hlwb vim nws tuaj yeem hla hauv cov ntshav-hlwb teeb meem. NACET tseem muab ntau yam los tiv thaiv kev tiv thaiv tsis zoo. NACET yuav tau noj ntawm qhov ncauj thiab pab ua kom muaj kev ci txhaws. Nws tuaj yeem tsim hauv tib neeg erythrocytes. NACET kuj tseem tuaj yeem coj ua tus neeg saib xyuas lub zog tiv thaiv cov kab mob hydroperoxide los tiv thaiv kev puas tsuaj. NACA muaj lub cev kev nyab xeeb zoo dua NAC ntxiv rau cov lwg me me los txhim kho qhov ua siab ntev thiab nyob hauv lub sijhawm ntawm bioscaffolds thiab biomaterials.

 

Lub hlwb

N-Acetyl-L-cysteine ​​ethyl ester hmoov 59587-09-6, yog cov khoom ntuj lossis hluavtaws uas tuaj yeem txhim kho lub hlwb ua haujlwm, txhim kho lub hlwb. Feem ntau hu ua Nootropics thiab cov tshuaj ntse, lawv tau muaj koob meej hauv zej zog cov kev sib tw niaj hnub no thiab feem ntau siv los txhawb kev nco, tsom, muaj tswv yim, txawj ntse thiab kev mob siab.

NACET nce mus rau ncig ua rau cov pa tshuaj hydrogen sulfide (H (2) S), yog li sawv cev rau tus neeg sib tw zoo rau kev siv lub qhov ncauj ua tus H (2) S cov tsim tawm, muaj qhov zoo dua NAC.

Tom qab kev kho mob ntawm qhov ncauj, NACET (tab sis tsis yog NAC) tau muaj peev xwm nce GSH cov ntsiab lus ntawm cov nqaij ntau nyob hauv cov nas (nrog rau lub hlwb), thiab tiv thaiv lawv los ntawm paracetamol intoxication.

 

Kev Noj Qab Haus Huv Noj Qab Haus Huv

Lub cev loj ntawm cov kev tshawb fawb thawj zaug pom tau hais tias kev noj zaub mov ntxiv nrog cov muaj zog antioxidant N-acetylcysteine ​​(NAC) tuaj yeem tiv thaiv kev rov ua RNA tus kab mob thiab txo qhov mob hnyav ntawm cov kab mob cuam tshuam.

Qhov kev hloov kho ntawm NAC no tso cai tsis muaj kev tiv thaiv koj cov ntshav ntshav los ntawm kev ua rau oxidative kev puas tsuaj, yog li ua rau koj lub cev tiv thaiv kab mob tiv thaiv koj lub cev kom zoo los ntawm kev puas tsuaj ntawm COVID-19 (Qhov no tsis yog lus qhia kho mob). NAC nws tus kheej muaj qhov ncauj qis qis dua vim tias nws tau nrawm rau hauv koj lub siab ua ntej nws tuaj yeem mus txog koj cov ntaub so ntswg, tshwj xeeb tshaj yog lub ntsws epithelium uas feem ntau muaj kev pheej hmoo rau COVID-19 ua rau muaj kev puas tsuaj.

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) siv?

Tsis ntev los no hauv cov chaw kuaj mob tsis txaus ntseeg kom paub meej tias qhov txiaj ntsig zoo ntawm N-acetylcysteine ​​(NAC) hauv kev tiv thaiv kab mob oxidative kev ntxhov siab. Qhov no tuaj yeem vim nws qhov qis qis dua ntawm bioavailability. Peb xav tias esterification ntawm pab pawg carboxyl ntawm NAC los tsim N-acetylcysteine ​​ethyl ester (NACET) yuav ruaj nce lipophilicity ntawm NAC, yog li txhim kho nws cov chaw muag tshuaj zoo heev. Hauv kev ua haujlwm tam sim no, peb qhia txog cov sawv cev tshuaj lom neeg, pharmacological thiab anti-oxidant zog ntawm NACET, tshwj xeeb tshaj yog nyob rau hauv kev sib piv ncaj qha nrog nws cov neeg ua haujlwm NAC. Peb pom tias NACET tau nrawm nrawm rau nas tom qab kev tswj hwm qhov ncauj tab sis mus txog ntau qhov tsis tshua muaj nyob hauv ntshav. Qhov no yog vim muaj qhov tshwj xeeb ntawm NACET: nws nrawm rau hauv lub hlwb qhov chaw uas nws tab cuab tau hloov mus rau hauv NAC thiab cysteine. Tom qab kev kho mob ntawm qhov ncauj, NACET (tab sis tsis yog NAC) tau muaj peev xwm nce cov ntsiab lus glutathione ntawm feem ntau cov ntaub so ntswg tau tshuaj xyuas, lub hlwb suav nrog, thiab tiv thaiv los ntawm paracetamol intoxication hauv cov nas. NACET tseem muaj qhov cim tshwj xeeb kom khaws hauv tib neeg erythrocytes qhov twg nws coj los ua cov muaj zog tiv thaiv kev tiv thaiv hydroperoxide los tiv thaiv kev puas tsuaj. Peb txoj kev tshawb fawb qhia tau tias nkag mus rau hauv hlwb thiab tsim NAC thiab cysteine, NACET nce ncig cov pa tshuaj hydrogen sulfide (H (2) S), yog li sawv cev rau cov neeg sib tw zoo rau kev siv lub qhov ncauj ua H (2) S cov khoom tsim, muaj qhov zoo meej dhau NAC. NACET muaj lub peev xwm hloov NAC los ua tus mucolytic tus neeg sawv cev, ua paracetamol antidote thiab ua GSH cuam tshuam los tiv thaiv kab mob.

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) Daim ntawv thov

NACET (N-Acetylcysteine ​​ethyl ester) yog cov tshiab lipophilic cell-permeable cysteine ​​derivative nrog ib qho txawv txawv pharmacokinetic thiab qhov muaj peev xwm ua tau antioxidant. NACET muaj qhov ncauj qhov ncauj siab zoo txaus. Nws yog cov tshuaj tua kab mob ua kom muaj zog thiab nplua nuj ua ntej ntawm GSH, uas cuam tshuam txog nws cov kua qaub dawb N-acetyl -L sib txawv ntawm -cysteine ​​(NAC). NACET yog cov hmoov dawb dawb hauv chav tsev sov thiab dawb do rau hauv dej thiab cov kuab tshuaj organic.

NAC yog ib qho kev sib txuas ntawm cysteine. Txij li xyoo 1970, nws tau siv los kho cov neeg mob acetaminophen overdose thiab neurological, thiab tau muag raws li cov tshuaj thiab cov khoom noj khoom haus ntxiv. Piv nrog NAC, NACET muaj lipophilicity siab dua thiab muaj cov tshuaj zoo dua. Nws muaj lub peev xwm los hloov cov tshuaj pharmacological NAC, raws li tus neeg sawv cev mucolytic, tshuaj tiv thaiv kab mob, tus xa khoom GSH, paracetamol antidote, thiab tsawg kawg yog tus pub khoom ntawm gaseous transmitter H 2 S thiab UV tus neeg sawv cev tiv thaiv.

Ntxiv rau, qhov muaj zog nucleophilicity thiab txo peev xwm ntawm NACET kuj tseem muaj pov thawj hauv tib neeg cov ntshav liab. Nws tau pom tias tau sau ntau ntxiv hauv tib neeg cov ntshav liab, muaj lub zog tiv thaiv kev puas tsuaj los ntawm hydroperoxides. Yog li, qhov peev xwm ntawm NACET los ua cov tshuaj tiv thaiv nitrite-ntxias cov tshuaj muaj zog ntau dua li ntawm NAC methemoglobinemia thiab lwm yam muaj zog oxidants. Cov kev tshawb fawb hauv cov nas tau pom tias NACET yog nqus tau nrawm dua NAC thaum NACET muab qhov ncauj. Nws muaj peev xwm nkag mus rau hauv cov hlwb thiab tsim NAC thiab cysteine, uas nce hydrogen sulfide (H (2) S) hauv kev ncig. Nws yog tus neeg sib tw zoo rau kev siv lub qhov ncauj ua H (2) S tus tsim tawm,

 

NACET hmoov kev muag khoom(Qhov twg Yuav NACET hmoov nyob rau hauv ntau)

Peb lub tuam txhab txaus siab rau kev sib raug zoo ntev nrog peb cov neeg vim tias peb tsom mus rau cov neeg siv khoom thiab muab cov khoom zoo. Yog tias koj txaus siab rau peb cov khoom lag luam, peb yoog tau nrog kho kom haum cov kev txiav txim siab kom haum koj cov kev xav tau tshwj xeeb thiab peb lub sijhawm ceev ceev ntawm kev txiav txim tau lees tias koj yuav tau saj zoo peb cov khoom kom raws sijhawm. Peb kuj tseem tsom rau kev pabcuam ntxiv tus nqi. Peb muaj nyob rau cov lus nug kev pabcuam thiab cov ntaub ntawv los txhawb koj txoj kev lag luam.

Peb yog tus kws tshaj lij ntawm NACET hmoov rau ntau xyoo, peb muab cov khoom lag luam nrog tus nqi sib tw, thiab peb cov khoom yog qhov ua tau zoo tshaj plaws thiab muaj kev nruj me ntsis, kev kuaj xyuas ywj pheej kom ntseeg tau tias nws muaj kev nyab xeeb rau kev noj nyob thoob ntiaj teb.

 

References

[1] N-acetylcysteine ​​ethyl ester ua GSH txhim kho hauv tib neeg lub hlwb endothelial: Ib txoj kev sib piv nrog lwm cov tshuaj. 2018 Lub Kaum Hli; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.

[2] N-acetylcysteine ​​ethyl ester ua GSH txhim kho hauv tib neeg lub hlwb endothelial: Ib txoj kev sib piv nrog lwm cov tshuaj. 2018 Lub Kaum Hli; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.

[3] S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) thiab N-acetyl-L-cysteine ​​ethyl ester (NACET) -Cov neeg sib tw siv tshuaj yaj yeeb nrog cov cim tshuaj kho mob rau qhov ncauj siv tsis tau, H2S thiab GSH cov neeg muab khoom thiab raws li cov tshuaj tiv thaiv antioxidant: Cov txiaj ntsig thiab kev saib xyuas. 2018 Lub Ob Hlis; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Dec 13. Rov Los Saib. PMID: 29568662.

 


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