Palmitoylethanolamide (PEA) (544-31-0) Chaw Tsim Tshuaj - Cofttek

Palmitoylethanolamide (PEA) (544-31-0)

Plaub Hlis Ntuj 7, 2020

Palmitoylethanolamide (PEA), ib qho endogenous (tsim tawm los ntawm lub cev) fatty acid amide, tau tawm los ua tus neeg sawv cev tshiab hauv kev kho mob thiab mob. Raws li cov kab mob endogenous thiab ib qho kuj pom muaj hauv cov zaub mov xws li qe thiab mis nyuj, tsis muaj kev phiv loj heev los sis tshuaj – qhia txog kev siv tshuaj yeeb.

 


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 1kg / hnab, 25kg / Nruas

Palmitoylethanolamide (PEA) (544-31-0) video

 

Palmitoylethanolamide (PEA) Specifications

 

Lub npe: Palmitoylethanolamide (PEA)
CAS: 544-31-0
purity 98% Micronized PEA ; 98% hmoov
Cov mis qauv: C18H37NO2
Lub cev nyhav: 299.49 g / mol
Melt Point: 93 rau 98 ° C
Tshuaj lub npe: Hydroxyethylpalmitamide Palmidrol N-Palmitoylethanolamine Palmitylethanolamide
txhais: Palmitoylethanolamide

Palmidrol

N- (2-Hydroxyethyl) hexadecanamide

N-palmitoylethanolamine

Qhov tseem ceeb hauv InChI: HXYVTAGFYLMHSO-UHFFFAOYSA-N
Ib nrab neej: 8 teev
Dej Cev: Soluble hauv DMSO, Methanol, Dej
Cia Kev Mob: 0 - 4 C rau lub sij hawm luv (hnub rau lis piam), lossis -20 C rau lub sij hawm ntev (hli)
daim ntawv thov: Palmitoylethanolamide (PEA) yog koom nrog tsev neeg endocannabinoid, ib pawg ntawm cov rog fatty amides. PEA tau muaj pov thawj ua kom muaj kev ua kom loog thiab kev ua haujlwm tiv thaiv thiab tau siv nyob rau hauv ntau txoj kev tshawb fawb tau tsom mus rau kev tswj hwm kev mob tshwm sim ntawm cov neeg mob cov neeg laus uas muaj cov sib txawv hauv chaw kho mob.
tsos: Dawb hmoov

 

Palmitoylethanolamide yog dab tsi (544-31-0)?

Palmitoylethanolamide (PEA), ib qho endogenous (tsim tawm los ntawm lub cev) fatty acid amide, tau tawm los ua tus neeg sawv cev tshiab hauv kev kho mob thiab mob. Raws li cov kab mob endogenous thiab ib qho kuj pom muaj hauv cov zaub mov xws li qe thiab mis nyuj, tsis muaj kev phiv loj heev los sis tshuaj – qhia txog kev siv tshuaj yeeb. PEA tau pom tias qhov ua tau zoo rau kev mob ntsws ntawm ntau hom cuam tshuam nrog ntau yam mob, tshwj xeeb tshaj yog mob neuropathic (hlab ntaws) mob, mob mob thiab visceral mob xws li endometriosis thiab interstitial cystitis.

 

Palmitoylethanolamide (544-31-0) txiaj ntsig

Thaum xub thawj, nws txo qis, dhau ntawm peroxisome proliferator-activated receptor alpha (PPARα), kev nrhiav neeg ua haujlwm thiab ua kom cov mast hlwb ntawm qhov chaw ntawm cov hlab ntaws raug mob thiab tso tawm ntawm cov kho kom haum xeeb los ntawm cov hlwb no; qhov thib ob, nws inhibits lub microglia kev ua kom zoo thiab kev rov ua haujlwm ntawm mast hlwb mus rau tus txha caj qaum tom qab mob puas hlwb, raws li ua raws li cov leeg hlwb neuroinflammation lossis mob hlwb txha caj qaum.

Ntau cov kev tshawb fawb tau tsom mus rau kev siv PEA hauv kev muaj ntau ntawm cov mob tsis zoo. Piv txwv li, nws tuaj yeem muaj txiaj ntsig zoo li adjuvant rau kev kho mob mob nraub qaum qis lossis nws tau siv ib leeg rau kev tswj hwm tus mob mus rau hauv cov neeg laus cov neeg mob hnyav, qhov twg siv cov tshuaj loog ua kom zoo tuaj yeem ua rau muaj kev pheej hmoo mob siab. Txhawb nqa cov txiaj ntsig tau pom nyob rau hauv kev kho mob tsis siv tshuaj kho radiculopathies nrog rau kev tsim cov tshuaj pleev PEA ultra-micronized ntawm PEA thiab kev sib koom ua ke nrog kev kho mob alpha-lipoic acid kom txo qis cov mob prostatitis / mob ntsws pelvic mob.

 

Palmitoylethanolamide (544-31-0) Mechanism Ntawm Kev Ua?

Palmitoylethanolamide (PEA) yog ib qho kev ua rau fatty acids amide endogenous, ib qho piv txwv ntawm endocannabinoid anandamide (AEA), uas zwm rau tsev neeg ntawm N-acylethanolamines (NAE). NAE raug tso tawm los ntawm cov hlwb hauv teb rau qhov tsis muaj zog. Raws li tag nrho cov NAEs, kuj PEA muaj cov txiaj ntsig hauv cheeb tsam, thiab nws cov ntaub so ntswg theem tau zoo tswj hwm los ntawm kev sib npaug ntawm kev tsim khoom thiab kev ua qias neeg. Ob qho kev tso dej nruab nrab, qhia nyob rau hauv cov roj hlwb, tau koom nrog lipid amide degradation: fatty-acid amide hydrolase (FAAH) thiab N-acylethanolamine hydrolyzing acid amidase (NAAA).

 

Palmitoylethanolamide (544-31-0) Daim ntawv thov

Palmitoylethanolamide (PEA) yog koom nrog tsev neeg endocannabinoid, ib pawg ntawm cov rog fatty amides. PEA tau muaj pov thawj ua kom muaj kev ua kom loog thiab kev ua haujlwm tiv thaiv thiab tau siv nyob rau hauv ntau txoj kev tshawb fawb tau tsom mus rau kev tswj hwm kev mob tshwm sim ntawm cov neeg mob cov neeg laus uas muaj cov sib txawv hauv chaw kho mob.

 

Palmitoylethanolamide (PEA) hmoov kev muag khoom(Qhov twg Yuav Palmitoylethanolamide (PEA) hmoov hauv qhov ntau)

Peb lub tuam txhab txaus siab rau kev sib raug zoo ntev nrog peb cov neeg vim tias peb tsom mus rau cov neeg siv khoom thiab muab cov khoom zoo. Yog tias koj txaus siab rau peb cov khoom lag luam, peb yoog tau nrog kho kom haum cov kev txiav txim siab kom haum koj cov kev xav tau tshwj xeeb thiab peb lub sijhawm ceev ceev ntawm kev txiav txim tau lees tias koj yuav tau saj zoo peb cov khoom kom raws sijhawm. Peb kuj tseem tsom rau kev pabcuam ntxiv tus nqi. Peb muaj nyob rau cov lus nug kev pabcuam thiab cov ntaub ntawv los txhawb koj txoj kev lag luam.

Peb yog tus kws tshaj lij Palmitoylethanolamide (PEA) hmoov tso rau ntau xyoo, peb muab cov khoom lag luam nrog cov nqi sib tw, thiab peb cov khoom yog qhov ua tau zoo tshaj plaws thiab yauv nruj, kev sim ywj siab kom ntseeg tau tias nws muaj kev nyab xeeb rau noj thoob ntiaj teb.

 

References

  • Hansen HS. Palmitoylethanolamide thiab lwm tus neeg sawv cev anandamide. Npaj lub luag haujlwm hauv cov kabmob hlwb. Exp Neurol. Xyoo 2010; 224 (1): 48–55
  • Petrosino S, Iuvone T, Di Marzo V. N-palmitoyl-ethanolamine: kev siv tshuaj lom neeg thiab tshuaj tshiab. Biochimie. Xyoo 2010; 92 (6): 724–7
  • Cerrato S, Brazis P, della Valle MF, Miolo A, Puigdemont A. Cov teebmeem ntawm palmitoylethanolamide ntawm kev tiv thaiv kab mob histamine, PGD2 thiab TNFα tawm los ntawm canine ntawm daim tawv nqaij mast hlwb. Vet Immunol Immunopathol. Xyoo 2010; 133 (1): 9–15
  • Palmitoylethanolamide (PEA): Txiaj Ntsig, Siv, Siv, Tshuaj Ntxiv