Chaw tsim tshuaj paus 7,8-DIHYDROXYFLAVONE | Tropoflavin - Cofttek

7,8-Dihydroxyflavone hmoov

Kaum ib hlis 23, 2021

Cofttek yog qhov zoo tshaj plaws 7,8-DIHYDROXYFLAVONE hmoov chaw tsim tshuaj paus hauv Suav teb. Peb lub Hoobkas muaj kev tswj hwm kev ua tiav (ISO9001 & ISO14001), nrog lub peev xwm ntau lawm txhua hli ntawm 260kg.


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 1kg / hnab, 25kg / Nruas

Specifications

Lub npe: 7,8-DIHYDROXYFLAVONE
CAS: 38183-03-8
purity 98%
Cov mis qauv: C15H10O4
Lub cev nyhav: 254.238 g / mol
Melt Point: 250-252 ° C
Tshuaj lub npe: Tropoflavin; 7,8- DHF
txhais: 7,8-dihydroxyflavone 38183-03-8 7,8-dihydroxy-2-phenyl-4H-chromen-4-ib 7,8-Dihydroxyflavone hydrate 7,8-DHF
Qhov tseem ceeb hauv InChI: COCYGNDDCWFKTMF-UHFFFAOYSA-N
Ib nrab neej: <30 feeb (hauv nas)
Dej Cev: 7,8-DHF yog soluble hauv cov kuab tshuaj organic xws li ethanol, DMSO, thiab dimethyl formamide (DMF).
Cia Kev Mob: 0 - 4 C rau lub sij hawm luv (hnub rau lis piam), lossis -20 C rau lub sij hawm ntev (hli)
daim ntawv thov: 7,8-DHF yog ib qho hluavtaws flavonoid uas tuaj yeem ncav cuag lub hlwb thiab qhib lub receptor (TrkB) uas txhawb kev loj hlob ntawm neuronal. Qee cov pov thawj tsiaj qhia tias 7,8-DHF yuav muaj qee qhov kev paub thiab lub cev muaj zog thiab tej zaum yuav yog nootropic.
tsos: Cov hmoov daj

 

7,8-DIHYDROXYFLAVONE (38183-03-8) yog dab tsi?

7,8-Dihydroxyflavone (7,8-DHF) yog ib qho flavone pom hauv cov nroj tsuag. Nws tau tshawb pom thaum tshawb nrhiav cov molecules uas ua raws li kev ua haujlwm ntawm lub hlwb-derived neurotrophic factor (BDNF).

BDNF txhawb kev loj hlob ntawm neurons thiab synapses (synaptogenesis) thiab tseem ceeb heev rau lub hlwb ua haujlwm. Kev txo qis ntawm BDNF tau pom hauv cov kab mob xws li kev nyuaj siab, Alzheimer's, Parkinson's, thiab schizophrenia.

Cov kev tshawb fawb hauv cov tsiaj pom tias 7,8-DHF tuaj yeem pab kho lub hlwb, kev nco mus ntev, kev nyuaj siab, thiab kab mob neurodegenerative.

 

7,8-DIHYDROXYFLAVONE (38183-03-8) cov kev pab cuam

Nco thiab Kawm

7,8-DHF txhim kho kev paub txog cov khoom (ib qho kev sim siv los txiav txim siab txog kev kawm thiab kev nco) hauv cov nas noj qab haus huv thaum muab tam sim tom qab thiab peb teev tom qab kawm. Nws kuj tseem txhim kho kev nco hauv nas nrog dementia. Hauv cov qauv nas ntawm kev puas siab puas ntsws post-traumatic stress disorder (PTSD), 7,8-DHF tiv thaiv kev ntxhov siab ntsig txog kev nco. 7,8-DHF kuj tseem txhim kho kev nco hauv cov nas laus.

 

Kho lub hlwb

7,8-DHF txhawb kev kho cov neurons puas. Nws kuj tseem ua rau kev tsim cov neurons tshiab hauv lub hlwb ntawm cov nas laus tom qab lub hlwb raug mob thiab txhawb kev loj hlob neuron hauv cov nas laus. Ib yam li ntawd, 7,8-DHF, nrog rau kev tawm dag zog, txhim kho lub hlwb ua haujlwm hauv cov nas uas muaj kev puas tsuaj rau lub hlwb.

 

Alzheimer Tus Kab Mob

Hauv cov qauv tsiaj rau Alzheimer's disease, 7,8-DHF:

Txo qhov tsim ntawm amyloid plaque

Txo oxidative kev nyuaj siab

Tiv thaiv kev poob ntawm synapses

Tiv thaiv kev nco tsis txaus thiab khaws cia kev paub txog kev ua haujlwm

Txawm li cas los xij, lwm txoj kev tshawb nrhiav pom tsis muaj txiaj ntsig hauv kev kho nas nrog Alzheimer's zoo li lub hlwb puas nrog 7,8-DHF.

 

Tus Kab Mob Ntawm Parkinson

7,8-DHF txhim kho lub cev muaj zog ua haujlwm thiab tiv thaiv kev poob ntawm dopamine ntsig txog neurons hauv tus qauv nas ntawm Parkinson tus kab mob.

Nws kuj tseem tiv thaiv kev tuag ntawm dopamine-sensitive neurons hauv cov qauv liab ntawm Parkinson tus kab mob.

 

7,8-DIHYDROXYFLAVONE (38183-03-8). siv?

7,8-Dihydroxyflavone (7,8-DHF) yog ib qho tshwm sim ntawm flavonoid. Nws tau pom tias muaj txiaj ntsig tiv thaiv ntau yam kab mob hauv lub paj hlwb, suav nrog Alzheimer's, Parkinson's, thiab Huntington's. 7,8-Dihydroxyflavone (7,8-DHF) yog xav tias yuav yog ib qho kev cog lus kho mob rau ntau yam kab mob neurodegenerative.

 

7,8-DIHYDROXYFLAVONE (38183-03-8). noj tshuaj

7,8-DHF tuaj yeem muas tau ua tshuaj ntsiav / tshuaj, lossis hmoov.

Tsis muaj kev nyab xeeb thiab siv tau zoo ntawm 7,8-DHF vim tias tsis muaj kev tshawb fawb muaj zog txaus los nrhiav ib qho. Qhov ntau npaum li cas hauv cov tshuaj muaj muag yog 10 - 30 mg ib hnub twg.

 

7,8-DIHYDROXYFLAVONE hmoov kev muag khoom(Qhov Yuav Yuav 7,8-DIHYDROXYFLAVONE hmoov nyob qhov twg)

Peb lub tuam txhab txaus siab rau kev sib raug zoo ntev nrog peb cov neeg vim tias peb tsom mus rau cov neeg siv khoom thiab muab cov khoom zoo. Yog tias koj txaus siab rau peb cov khoom lag luam, peb yoog tau nrog kho kom haum cov kev txiav txim siab kom haum koj cov kev xav tau tshwj xeeb thiab peb lub sijhawm ceev ceev ntawm kev txiav txim tau lees tias koj yuav tau saj zoo peb cov khoom kom raws sijhawm. Peb kuj tseem tsom rau kev pabcuam ntxiv tus nqi. Peb muaj nyob rau cov lus nug kev pabcuam thiab cov ntaub ntawv los txhawb koj txoj kev lag luam.

Peb yog ib tus kws tshaj lij 7,8-DIHYDROXYFLAVONE hmoov khoom muag tau ntau xyoo, peb muab cov khoom lag luam nrog cov nqi sib tw, thiab peb cov khoom yog cov khoom zoo tshaj plaws thiab dhau mus nruj, ywj siab kuaj kom ntseeg tau tias nws muaj kev nyab xeeb rau kev noj thoob ntiaj teb.

 

References

  1. Schliebs R, Arendt T (2006) Qhov tseem ceeb ntawm cov kab mob cholinergic hauv lub hlwb thaum laus thiab hauv Alzheimer's disease. J Neural Transm (Vienna) 113:1625–1644.
  2. Corbett A, Ballard C (2012) Kev kho tshiab thiab tawm tshiab rau Alzheimer's disease. Expert Opin Emerg Drugs 17:147–156.
  3. Giacobini E, Kub G (2013) Alzheimer kab mob kho: Tsiv ntawm amyloid-β rau tau. Nat Rev Neurol 9:677–686.
  4. Zuccato C, Cattaneo E (2009) Lub hlwb-derived neurotrophic yam hauv cov kab mob neurodegenerative. Nat Rev Neurol 5:311–322.

 


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