Qhov Zoo Citicoline Sodium (33818-15-4) Chaw Tsim Tshuaj - Cofttek

Citicoline Sodium (33818-15-4)

Tej zaum 8, 2021

Cofttek yog qhov zoo tshaj plaws Citicoline Sodium (CDP Choline Sodium) hmoov chaw tsim tshuaj paus hauv Suav teb. Peb lub Hoobkas muaj kev ua tiav kev tswj hwm kev tsim khoom (ISO9001 & ISO14001), nrog lub peev xwm tsim khoom txhua hli ntawm 220kg.

 


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 1kg / hnab, 25kg / Nruas

Citicoline Sodium (CDP Choline Sodium)(33818-15-4) Specifications

Lub npe: Citicoline Sodium (CDP Choline Sodium)
CAS: 33818-15-4
purity 98%
Cov mis qauv: C14H25N4NaO11P2
Lub cev nyhav: 510.308 g / mol
Melt Point: > 240 ° C
Tshuaj lub npe: Citicoline Sodium; Cdp-choline sodium
txhais: Sodium [[(2S,3R,4S,5S)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]2-(trimethylazaniumyl)ethyl phosphate
Qhov tseem ceeb hauv InChI: YWAFNFGRBBSPD-KDVMHAGBSA-M
Ib nrab neej: 56 teev
Dej Cev: Soluble hauv DMSO, Dej (Me ntsis)
Cia Kev Mob: Qhuav, tsaus thiab nyob rau hauv 0 - 4 C rau lub sij hawm luv (hnub mus rau lub lis piam) lossis -20 C rau lub sij hawm ntev (hli txog xyoo).
daim ntawv thov: Citicoline Sodium yog cov tshuaj tiv thaiv neuroprotective thiab kev noj haus ntxiv
tsos: Dawb Khoom ua hmoov

 

Citicoline Sodium hmoov (33818-15-4) NMR Spectrum NPE

Citicoline Sodium (33818-15-4) NMR Spectrum

Yog tias koj xav tau COA, MSDS, HNMR rau txhua qhov khoom seem thiab lwm yam ntaub ntawv, thov hu rau peb tus thawj tswj kev lag luam.

 

Yuav ua li cas yog Citicoline Sodium (CDP Choline Sodium)(33818-15-4) ?

Citicoline Sodium (CDP-choline Sodium, cytidine 5′-diphosphocholine) hmoov yog cov dej zom cov khoom noj uas ua rau muaj kev cuam tshuam rau ob choline thiab cytidine hauv lub hlwb (uas tom qab hloov mus rau uridine). Rau tib neeg, Citicoline Sodium yog qhov muaj txiaj ntsig zoo li lub luag haujlwm ntawm nws txo txoj kev pheej hmoo ntawm cov leeg ntshav tsis zoo, ua kom lub siab rog, thiab lwm cov kab mob pathologies tau teev tseg. CDP-choline Sodium yog ib qho ntawm peb lub choline-phospholipids uas tuaj yeem yog cov tshuaj ntxiv ntawm qhov ncauj (lwm qhov ob yog alpha-GPC thiab phosphatidylcholine).

 

Citicoline Sodium (CDP Choline Sodium)(33818-15-4) cov kev pab cuam

CDP-choline ua rau lub biosynthesis ntawm cov txheej txheem phospholipids nyob rau hauv cov hlab ntsha neuronal, nce ntxiv cov kab mob cerebral thiab ua rau theem ntawm ntau cov neurotransmitters. Yog li, nws tau sim ua pov thawj tias CDP-choline nce rau qib noradrenaline thiab dopamine ntau hauv CNS.

Qhov no ntxiv yog catered rau kev tiv thaiv los yog kev kho cov teeb meem nco kev cuam tshuam nrog kev laus vim tias ob qho tib si ntawm lub molecules nws confers yog neuroprotective thiab feem ntau txhawb txoj kev kawm. Thaum nws zoo li zoo tshaj phosphatidylcholine (PC) ntawm lub luag hauj lwm no, vim ib qho vim tseem muaj PC synthesis nyob rau hauv lub hlwb, nws lub zog yog me ntsis piv rau cov Alpha-GPC.

 

Citicoline Sodium (CDP Choline Sodium)(33818-15-4) siv

CDP-choline muaj qee yam siv rau hauv kev txheeb ze rau kev nkag siab. Nws nquag siv los ua lub cim xeeb txhim kho hauv cov hluas, tab sis txawm tias qee qhov kev tshawb fawb nqaj pom tias qhov no ua tau nrog lub qhov ncauj CDP-choline, tsis muaj tib neeg kev tshawb fawb txog cov hluas hauv lub sijhawm no. Ib txoj kev tshawb nrhiav tau sau tseg qhov kev nce siab nrog kev noj tshuaj tsawg tsawg CDP-choline (uas yuav tsum tau rov ua dua), thiab CDP-choline tuaj yeem muaj lub luag haujlwm ua cov tshuaj tiv thaiv zoo rau ob qho yeeb tshuaj yeeb thiab (cov pov thawj ua ntej pom zoo) cov zaub mov thiab ..

 

Citicoline Sodium (CDP Choline Sodium)(33818-15-4) Daim ntawv thov

Citicoline Sodium (CDP Choline Sodium) hmoov yog cov tshuaj tiv thaiv neuroprotective. Nws ua los ntawm kev txhim kho kev sib txuas lus ntawm tes, txhawb txoj kev sib txuas ntawm SAMe, thiab nce cov piam thaj hauv ntshav ntau ntau. Citicoline Sodium (CDP Choline Sodium) hmoov yog lub sijhawm muaj paug nucleotide; nruab nrab hauv txoj kev loj ntawm lecitin biosynthesis. Neuroprotective. Nws yog siv rau hauv kev kho mob ischemic stroke thiab mob taub hau. Neuroprotectiveproduct. Citicholine ua rau pom kev tiv thaiv kab mob rau hauv cerebral ischemia, raug mob rau lub hlwb, thiab nco txog kev ntshawv siab. Tsis ntev los no tau pom kev ua tau zoo tiv thaiv kev dementia thaum muab nrog AchEIs (Acetylcholinesterase inhibitor). Cov tshuaj tiv thaiv Neuroprotective, acnticonvulsant kev ua si thiab sedative nyhuv ntawm koob tshuaj 150mg / kg hauv nas. Qhia kev tiv thaiv tiv thaiv txhuas tiv thaiv qhov ua rau lub cev tsis ua haujlwm ntawm cov nas txo qis nce glutamate qib, oxidativestress thiab TSIS muaj kev ua haujlwm ntau hauv hippocampus.

 

Citicoline Sodium (CDP Choline Sodium)(33818-15-4) hmoov kev muag khoom

(Qhov Twg Yuav Citicoline Sodium (CDP Choline Sodium)(33818-15-4) hmoov hauv ib qho)

Peb lub tuam txhab txaus siab rau kev sib raug zoo ntev nrog peb cov neeg vim tias peb tsom mus rau cov neeg siv khoom thiab muab cov khoom zoo. Yog tias koj txaus siab rau peb cov khoom lag luam, peb yoog tau nrog kho kom haum cov kev txiav txim siab kom haum koj cov kev xav tau tshwj xeeb thiab peb lub sijhawm ceev ceev ntawm kev txiav txim tau lees tias koj yuav tau saj zoo peb cov khoom kom raws sijhawm. Peb kuj tseem tsom rau kev pabcuam ntxiv tus nqi. Peb muaj nyob rau cov lus nug kev pabcuam thiab cov ntaub ntawv los txhawb koj txoj kev lag luam.

Peb yog tus kws tshaj lij Citicoline Sodium (CDP Choline Sodium)(33818-15-4) hmoov muab khoom siv tau ob peb xyoos, peb muab cov khoom lag luam nrog tus nqi sib tw, thiab peb cov khoom yog qhov zoo tshaj plaws thiab muaj kev nruj me ntsis, kev kuaj xyuas ywj pheej kom ntseeg tau tias nws muaj kev nyab xeeb rau noj thoob ntiaj teb.

 

References

[1] Tyurenkov IN, Kurkin DV, Bakulin DA, Volotova EV, Chafeev MA. [Cerebroprotective kev ua haujlwm ntawm metformin, gosogliptin, citicoline thiab ib qho tshiab GPR119 agonist hauv cerebral ischemia nyob hauv kev sim ntshav qab zib mellitus]. Zh Nevrol Psikhiatr Im SS Korsakova. 2017; 117 (12. Vyp. 2): 53-59. doi: 10.17116 / jnevro201711712253-59. Lavxias. PubMed PMID: 29411746.

[2] Jiang JJ, Xie YM, Zhang Y, Zhang YK, Wang ZM, Han B. [Cov tshuaj kho mob qhov sib txawv ntawm kev txhaj tshuaj Shuxuening hauv kev kho mob cerebral infarction tshawb xyuas raws li kev sau npe). Zhongguo Zhong Yao Za Zhi. 2016 Dec; 41 (24): 4516-4520. doi: 10.4268 / cjcmm20162407. Hmoob Suav Teb. PubMed PMID: 28936832.

[3] Liu Y, Wang J, Xu C, Chen Y, Yang J, Liu D, Niu H, Jiang Y, Yang S, Ying H. Efficient ntau-enzyme-catalyzed CDP-choline ntau lawm uas tau tsav los ntawm ATP hloov khoom siv. Ua li Microbiol Biotechnol. 2017 Lub Ob Hlis; 101 (4): 1409-1417. doi: 10.1007 / s00253-016-7874-0. Epub 2016 Oct 13. PubMed PMID: 27738720.

[4] Giménez R, Raïch J, Aguilar J (Nov 1991). "Kev hloov pauv ntawm lub hlwb striatum dopamine thiab acetylcholine receptors ntxias los ntawm kev kho mob CDP-choline ntev ntawm cov nas laus". Phau Ntawv Teev Ntawv Askiv Tshuaj. 104 (3): 575–8. doi: 1111 / j.1476-5381.1991.tb12471.x. PMC1908237PMID1839138.

[5] Lub tsev qub qub, P. (2020-08-30). "Kev siv cov citicoline rau kev kho mob ntawm kev txawj ntse poob qis thiab kev txawj ntse: Tshawb xyuas cov ntaub ntawv ntawm cov khw muag tshuaj • Cov Ntawv Xov Xwm Thoob Ntiaj Teb ntawm Ib Cheeb Tsam Kev Tshawb Fawb & Tshuab". Phau Ntawv Xov Xwm Thoob Ntiaj Teb ntawm Environmental Science & Technology. Nquag Xyoo 2020-08-31.