Nicotinamide Riboside Chloride (NR) (23111-00-4) Chaw Tsim Tshuaj - Cofttek

Nicotinamide Riboside Chloride (NR) (23111-00-4)

Plaub Hlis Ntuj 7, 2020

Nicotinamide riboside, tseem hu ua NR thiab SRT647, yog pyridine-nucleoside daim ntawv ntawm cov vitamin B3 uas ua haujlwm ua ntej rau nicotinamide adenine dinucleotide lossis NAD +. NR cov kev cuam tshuam los ntawm kev phais mob sib cais dorsal cag ganglion neurons ex vivo thiab tiv thaiv lub suab tsis hnov ​​lus zoo nyob hauv cov nas.

 


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 1kg / hnab, 25kg / Nruas

 

Nicotinamide Riboside Chloride (NR) (23111-00-4) video

 

Nicotinamide Riboside Chloride (NR) Specifications

Lub npe: Nicotinamide Riboside Chloride (NR)
CAS: 23111-00-4
purity 98%
Cov mis qauv: C11H15ClN2O5
Lub cev nyhav: 290.7 g / mol
Melt Point: 115-125 ℃
Tshuaj lub npe: 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
txhais: Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nicotinamide Riboside Triflate, β / β sib xyaw
Qhov tseem ceeb hauv InChI: YABIFCKURFRPPO-FSDYPCQHSA-N
Ib nrab neej: 2.7 teev
Dej Cev: Soluble hauv DMSO, Methanol, Dej
Cia Kev Mob: 0 - 4 C rau lub sij hawm luv (hnub rau lis piam), lossis -20 C rau lub sij hawm ntev (hli)
daim ntawv thov: Nicotinamide riboside tau lees tias yog ib daim ntawv tshiab pyridine-nucleoside ntawm vitamin B₃ uas ua haujlwm ua lub zog ua ntej rau nicotinamide adenine dinucleotide lossis NAD +.
tsos: Tawm Dawb rau Tawv daj hmoov

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 yog dab tsi?

Nicotinamide riboside, tseem hu ua NR thiab SRT647, yog pyridine-nucleoside daim ntawv ntawm cov vitamin B3 uas ua haujlwm ua ntej rau nicotinamide adenine dinucleotide lossis NAD +. NR cov kev cuam tshuam los ntawm kev phais mob sib cais dorsal cag ganglion neurons ex vivo thiab tiv thaiv lub suab tsis hnov ​​lus zoo nyob hauv cov nas. Nicotinamide riboside tiv thaiv cov leeg, neural thiab melanocyte qia cell senescence. Ua kom cov nqaij ntshiv nce ntxiv hauv cov nas tau raug pom tom qab kho nrog nicotinamide riboside, ua rau muaj kev cia siab tias nws yuav txhim kho kev ua kom rov ua haujlwm ntawm cov nruab nrog xws li lub siab, raum, thiab plawv. Nicotinamide riboside kuj ua rau cov ntshav qabzib thiab cov rog nyob hauv cov neeg mob ntshav qab zib thiab hom 2 mob ntshav qab zib thaum tiv thaiv kev txhim kho kev mob ntshav qab zib peripheral neuropathy. Lus Cim: Nicotinamide Riboside chloride yog kev sib xyaw α / β

 

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 cov txiaj ntsig

Nicotinamide nucleosides yog qhov ua ntej ntawm nicotinamide adenine dinucleotide (NAD) thiab sawv cev rau cov khoom siv ntawm vitamin B3. Cov kev tshawb fawb tsis ntev los no tau pom tias kev noj ntau npaum li cas ntawm nicotinamide nucleosides ib txwm muaj hauv cov zaub mov tuaj yeem muab cov txiaj ntsig kev noj qab haus huv tshiab. Piv txwv, nicotinamide nucleosides tau txais qhov cuam tshuam hauv kev nce hauv cov nqaij mos NAD concentration thiab inulin insulin rhiab li txhim kho sirtuin muaj nuj nqi. Nws lub peev xwm los nce NAD ntau lawm qhia tias nicotinamide nucleosides kuj tseem tuaj yeem txhim kho mitochondrial kev noj qab haus huv, txhawb kev ua haujlwm mitochondrial, thiab ntxias cov mitochondria tshiab. Lwm yam kev tshawb fawb siv nicotinamide nucleosides hauv Alzheimer tus qauv kab mob tau pom tias cov lwg me me muaj nyob rau hauv lub hlwb thiab tuaj yeem muab cov neuroprotection los ntawm kev txhawb cov hlwb NAD synthesis.

Nicotinamide Riboside Chloride kuj tuaj yeem txo qhov hnyav: Kev tshawb fawb pom tau tias los ntawm kev nce lub zog hauv lub cev, koj tuaj yeem txo cov khoom noj muaj roj ntau ntau hauv lub cev nyhav. Txhawm rau ntsuas lub nicotinamide ribose mechanism ntawm NR txhawb kev poob phaus, cov neeg tshawb nrhiav ntsuas lub siab mitochondrial muaj nuj nqi txuam nrog caloric kom tsawg, kev ua si, calories, lub duav ib puag ncig, so tus nqi metabolic, lub cev muaj pes tsawg, muaj siab ntev, insulin rhiab heev thiab ntau yam biochemical thiab metabolomics tsis. Cov ntaub ntawv no thiab cov ua kom poob phaus tshiab los ntawm malabsorption, kev nthuav tawm ntawm cov cim roj ntsha rau kev taug qab. Cov kws tshawb nrhiav tau tshaj tawm tias cov nas noj cov zaubmov nicotinamide muaj txiaj ntsig zoo rau kev poob phaus ntawm cov nas uas tsis ntxiv cov tshuaj nicotinamide.

 

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 Mechanism Ntawm Kev Ua?

Nicotinamide Riboside Chloride (NR) nucleosides yog cov muaj ua ntej ntawm nicotinamide adenine dinucleotide (NAD) thiab sawv cev rau qhov chaw muaj vitamin B3. Cov kev tshawb fawb tsis ntev los no tau pom tias kev noj ntau npaum li cas ntawm nicotinamide nucleosides ib txwm muaj hauv cov zaub mov tuaj yeem muab cov txiaj ntsig kev noj qab haus huv tshiab. Piv txwv, nicotinamide nucleosides tau txais qhov cuam tshuam hauv kev nce hauv cov nqaij mos NAD concentration thiab inulin insulin rhiab li txhim kho sirtuin muaj nuj nqi. Nws lub peev xwm los nce NAD ntau lawm qhia tias nicotinamide nucleosides kuj tseem tuaj yeem txhim kho kev noj qab haus huv mitochondrial, txhawb kev ua mitochondrial, thiab ntxias cov mitochondria tshiab. Lwm yam kev tshawb fawb uas siv nicotinamide nucleosides nyob rau hauv Alzheimer tus qauv kab mob tau qhia tias cov lwg me me muaj nyob rau hauv lub hlwb thiab yuav muab cov neuroprotection los ntawm kev txhawb nqa lub hlwb NAD synthesis ..

 

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 Daim ntawv thov

Cov kev tshawb fawb pom tau qhia tias qhov sib ntxiv ntawm nicotinamide ribose tsis tuaj yeem tsuas yog nce NAD + qib kev nyab xeeb, tab sis kuj tseem siv qhov kev siv NAD + ntau tshaj nyob hauv tib neeg, uas tsis tau muaj nrog lwm cov vitamin B3. Cov neeg qhia tau pom tias ib zaug nicotinamide ribose tshwm hauv lub cell, lub cev hloov pauv nws mus rau hauv NAD +. Cov NAD + no tsim kho cov txheej txheem ntawm intracellular pib ntawm lub zog tsim khoom los ntawm mitochondria

Nicotinamide Riboside Chloride tuaj yeem txhim kho mitochondrial muaj nuj nqi, uas tau pom tias txhim kho cov lus qhia ntawm mitochondrial electron thauj saw cov protein, txhim kho mitochondrial membrane muaj peev xwm, thiab nce tus nqi ntawm oxidative respiration thiab intracellular ATP qib. Qhov no tuaj yeem nrog cov qib siab ntawm kev tsim kho mitochondrial. Cov haujlwm ua haujlwm Mitochondrial poob qis thaum peb hnub nyoog, thiab qhov no yog lub cim ntawm kev laus ntawm cov qia hlwb uas peb pom. NR tuaj yeem txhim kho kev ua haujlwm ntawm mitochondria thiab inhibit thees ntawm qog hlwb.

 

Nicotinamide Riboside Chloride (NR) hmoov kev muag khoom(Qhov twg Yuav Qhov Zoo Tshuaj Nicotinamide Riboside Chloride (NR) hmoov hauv qhov ntau)

Peb lub tuam txhab txaus siab rau kev sib raug zoo ntev nrog peb cov neeg vim tias peb tsom mus rau cov neeg siv khoom thiab muab cov khoom zoo. Yog tias koj txaus siab rau peb cov khoom lag luam, peb yoog tau nrog kho kom haum cov kev txiav txim siab kom haum koj cov kev xav tau tshwj xeeb thiab peb lub sijhawm ceev ceev ntawm kev txiav txim tau lees tias koj yuav tau saj zoo peb cov khoom kom raws sijhawm. Peb kuj tseem tsom rau kev pabcuam ntxiv tus nqi. Peb muaj nyob rau cov lus nug kev pabcuam thiab cov ntaub ntawv los txhawb koj txoj kev lag luam.

 

Peb yog tus kws tshaj lij Nicotinamide Riboside Chloride (NR) hmoov tso rau ntau xyoo, peb muab cov khoom lag luam nrog cov nqi sib tw, thiab peb cov khoom yog qhov zoo tshaj plaws thiab muaj kev soj ntsuam nruj, kev ywj pheej kom paub tseeb tias nws muaj kev nyab xeeb rau noj thoob ntiaj teb.

 

References

  • Chi Y, Sau AA. Nicotinamide riboside, ib txoj lw noj zaub mov hauv cov zaub mov, yog cov vitamin B3 uas muaj cov teebmeem ntawm lub zog metabolism thiab neuroprotection. Curr Opin Clin Nutr Metab Tu Neeg. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Ntsuam Xyuas. PubMed PMID: 24071780.
  • Bogan KL, Brenner C. Nicotinic acid, nicotinamide, thiab nicotinamide riboside: ib qho kev soj ntsuam molecular ntawm NAD + cov kab mob ua ntej cov vitamins hauv tib neeg cov khoom noj khoom haus. Annu Rev Nutr. Xyoo 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Ntsuam Xyuas. PubMed PMID: 18429699.
  • Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation ua cov cell-intrinsic, cov tsav tsheb hloov pauv ntawm cov rog cia: cov tshuaj lom thiab cov metabolism hauv kev hloov kho ntawm acetyl-lysine kev hloov kho. Ntxov Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Ntsuam Xyuas. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.
  • Txhua Yam Koj Yuav Tsum Tau Paub Txog Nicotinamide Riboside Chloride