N-Methyl-DL-asparticacid (17833-53-3) Chaw tsim tshuaj paus - Cofttek

N-Methyl-DL-asparticacid (17833-53-3)

Lub rau hli ntuj 29, 2022

Cofttek yog qhov zoo tshaj plaws N-Methyl-DL-asparticacid (17833-53-3) chaw tsim tshuaj paus hauv Suav teb. Peb lub Hoobkas muaj kev tswj hwm kev ua tiav (ISO9001 & ISO14001), nrog lub peev xwm ntau lawm txhua hli ntawm 260kg.


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 1kg / hnab, 25kg / Nruas

N-Methyl-DL-asparticacid Specifications

Lub npe: N-Methyl-DL-asparticacid
CAS: 17833-53-3
purity 98%
Cov mis qauv: C5H9NO4
Lub cev nyhav: 147.130 g / mol
Cov ntsiab lus Melting: 189-190 C ib
Tshuaj lub npe: (2R)-2-(Methylamino)butanedioic acid
txhais: N-Methylaspartate; N-Methyl-D-aspartate; NMDA
Qhov tseem ceeb hauv InChI: HOKKHZGPKSLGJE-GSVOUGTGSA-N
Ib nrab neej: N / A
Dej Cev: Soluble hauv dej; Ethanol; DMSO
Cia Kev Mob: 0 - 4 C rau lub sij hawm luv (hnub rau lis piam), lossis -20 C rau lub sij hawm ntev (hli)
daim ntawv thov: N-methyl-D-aspartic acid los yog N-methyl-D-aspartate yog ib qho amino acid derivative uas ua raws li ib tug tshwj xeeb agonist ntawm NMDA receptor mimicking qhov kev txiav txim ntawm glutamate, cov neurotransmitter uas ib txwm ua ntawm tus receptor.
tsos: Dawb hmoov

 

N-Methyl-DL-asparticacid (17833-53-3) yog dab tsi?

N-Methyl-DL-Aspartic Acid (NMDLA) sawv cev rau kev sib xyaw ntawm D thiab L enantiomers (NMDA; NMLA). Txhua enantiomer muaj cov dej num sib txawv thiab cov ntaub so ntswg sib txawv / hom abundances. Yog li ntawd, txhua tus enantiomer yuav tsum tau txiav txim siab cais. NMDA yog ib qho kev kawm dav neurotoxin uas yog ib qho agonist ntawm NMDA receptor thiab induces hlwb legions. NMDA feem ntau tsis pom muaj nyob hauv cov ntaub so ntswg, thaum NMLA tuaj yeem pom nyob rau hauv qee qhov bivalves.

 

N-Methyl-DL-asparticacid (17833-53-3) cov txiaj ntsig

NMDA (N-methyl-D-aspartic acid) yog ib tug dav paub agonist rau ib chav kawm ntawm glutamate receptors, hom NMDA. Synthetic NMDA elicits muaj zog heev kev ua si rau induction ntawm hypothalamic yam thiab hypophyseal cov tshuaj hormones nyob rau hauv cov tsiaj. Ntxiv mus, endogenous NMDA tau pom nyob rau hauv nas, qhov uas nws muaj lub luag hauj lwm nyob rau hauv lub induction ntawm GnRH (Gonadotropin Releasing Hormone) nyob rau hauv lub hypothalamus, thiab ntawm LH (Luteinizing Hormone) thiab PRL (Prolactin) nyob rau hauv lub pituitary caj pas.

 

N-Methyl-DL-asparticacid (17833-53-3) Daim ntawv thov?

N-methyl-d-aspartic acid los yog N-methyl-d-aspartate (NMDA) yog ib qho amino acid derivative uas ua raws li ib tug tshwj xeeb agonist ntawm NMDA receptor mimicking qhov kev txiav txim ntawm glutamate, cov neurotransmitter uas ib txwm ua ntawm tus receptor. Tsis zoo li glutamate, NMDA tsuas yog khi rau thiab tswj cov NMDA receptor thiab tsis muaj kev cuam tshuam rau lwm cov glutamate receptors (xws li cov AMPA thiab kainate). NMDA receptors yog qhov tseem ceeb tshwj xeeb tshaj yog thaum lawv dhau los ua haujlwm dhau sijhawm, piv txwv li, tshem tawm ntawm cawv vim qhov no ua rau cov tsos mob xws li kev ntxhov siab thiab, qee zaum, qaug dab peg.

 

N-Methyl-DL-asparticacid hmoov kev muag khoom(Qhov twg Yuav N-Methyl-DL-asparticacid hmoov hauv ntau)

Peb lub tuam txhab txaus siab rau kev sib raug zoo ntev nrog peb cov neeg vim tias peb tsom mus rau cov neeg siv khoom thiab muab cov khoom zoo. Yog tias koj txaus siab rau peb cov khoom lag luam, peb yoog tau nrog kho kom haum cov kev txiav txim siab kom haum koj cov kev xav tau tshwj xeeb thiab peb lub sijhawm ceev ceev ntawm kev txiav txim tau lees tias koj yuav tau saj zoo peb cov khoom kom raws sijhawm. Peb kuj tseem tsom rau kev pabcuam ntxiv tus nqi. Peb muaj nyob rau cov lus nug kev pabcuam thiab cov ntaub ntawv los txhawb koj txoj kev lag luam.

Peb yog ib tus kws tshaj lij N-Methyl-DL-asparticacid hmoov khoom muag tau ntau xyoo, peb muab cov khoom lag luam nrog tus nqi sib tw, thiab peb cov khoom yog qhov zoo tshaj plaws thiab dhau mus nruj, kev sim ywj pheej kom ntseeg tau tias nws muaj kev nyab xeeb rau kev noj thoob ntiaj teb.

 

References

  1. "N-Methylaspartate - Cov Lus Tso Lus Me Me". PubChem Hom. Tebchaws Asmeskas: Lub Chaw Hauv Tebchaws rau Cov Ntaub Ntawv Biotechnology. 24 Lub Rau Hli 2005. Kev Qhia Txog Tus Kheej. Txuas 9 Lub Ib Hlis 2012.
  2. Watkins, JC (Lub Kaum Ib Hlis 1962). "Lub synthesis ntawm qee cov acidic amino acids muaj cov haujlwm neuropharmacological". Phau ntawv Journal of Medicinal and Pharmaceutical Chemistry. 5 (6): 1187–1199.
  3. Buhusi, CV; Oprisan, SA; Buhusi, M (Lub Plaub Hlis 2016). "Lub Sij Hawm Hauv Lub Sij Hawm: Lub Sijhawm los ntawm Kev Tshawb Fawb Txog Kev Pom Zoo". Kev xav tam sim no hauv Behavioral Sciences. 8:207–213.

 


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