Adelmidrol (1675-66-7) Chaw tsim tshuaj paus - Cofttek

Adelmidrol (1675-66-7)

Lub rau hli ntuj 29, 2022

Cofttek yog qhov zoo tshaj plaws Adelmidrol (1675-66-7) chaw tsim tshuaj paus hauv Suav teb. Peb lub Hoobkas muaj kev tswj hwm kev ua tiav (ISO9001 & ISO14001), nrog lub peev xwm ntau lawm txhua hli ntawm 260kg.


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 1kg / hnab, 25kg / Nruas

Adelmidrol Specifications

Lub npe: Adelmidrol
CAS: 1675-66-7
purity 98%
Cov mis qauv: C13H26N2O4
Lub cev nyhav: 274.36 g / mol
Cov ntsiab lus Melting: 132-134 C ib
Tshuaj lub npe: N, N'-Bis (2-hydroxyethyl) nonanediamide
txhais: Adelmidrol 1675-66-7 N, N'-bis (2-hydroxyethyl) nonanediamide AdelMitrol UNII-1BUC3685QU Ntau…
Qhov tseem ceeb hauv InChI: PAHZPHDAJQIETD-UHFFFAOYSA-N
Ib nrab neej: N / A
Dej Cev: Soluble hauv dej; Ethanol; DMSO
Cia Kev Mob: 0 - 4 C rau lub sij hawm luv (hnub rau lis piam), lossis -20 C rau lub sij hawm ntev (hli)
daim ntawv thov: Nws yog siv dav hauv Ltalis hauv cov tshuaj kho tsiaj los kho cov tawv nqaij o. Hauv xyoo 2015, nws tau pom tias qhov sib xyaw ua ke kuj tseem siv tshuaj tiv thaiv kab mob uas tau muab rau hauv 10 mg ib kg lub cev hnyav.
tsos: Dawb hmoov

 

Adelmidrol (1675-66-7) yog dab tsi?

Adelmidrol yog semisynthetic diethanolamide derivative ntawm azelaic acid, thiab muaj ib tug symmetrical tshuaj qauv. Nws tau faib ua amide, thiab zoo ib yam li palmitoylethanolamide, niam txiv molecule hauv ALIAmide chav kawm ntawm cov tshuaj. ALIAmides yog pab pawg ntawm fatty acid derivatives nrog cannabimimetic zog uas muaj kev tiv thaiv inflammatory thiab analgesic teebmeem thiab xav tias yuav ua los ntawm kev txo cov mast cell activation. Adelmidrol yog ib qho tshuaj tiv thaiv kab mob ethanolamide derivative ntawm azelaic acid.

 

Adelmidrol (1675-66-7) cov txiaj ntsig

Adelmidrol yog cov khoom siv hluavtaws ntawm azelaic acid, ib txwm tshwm sim saturated dicarboxylic acid, uas muaj nyob rau hauv qee cov nplej thiab hauv cov kab hauv tib neeg lub cev. Chemically, ademidrol yog N, N-bis (2-hydroxyethyl) tsis yog anediamide thiab nws yog ib qho amphiphilic lossis amphipathic compound, muaj ob qho tib si hydrophilic thiab hydrophobic zog, uas nyiam nws solubility ob qho tib si hauv aqueous thiab organic media. Adelmidrol belongs rau tsev neeg aliamide, ib pawg ntawm fatty acid derivatives nrog cannabimimetic zog, muaj peev xwm tswj mast cell (MC) hyperreactivity nyob rau hauv ntau yam pathophysiological thiab pathological mob. Pro-inflammatory NF-κB txoj hauv kev tau txo qis los ntawm kev kho nrog adelmidrol. Cov tshuaj tiv thaiv kab mob ntawm adelmidrol tau tshwm sim los ntawm kev ua kom PPAR-gamma. Adelmidrol yog tshuaj pleev ib ce rau tib neeg cov tawv nqaij inflammatory kab mob thiab muaj peev xwm hloov kho cov inflammatory teb nyob rau hauv tib neeg keratinocytes. Kev sib xyaw ntawm hyaluronic acid thiab adelmidrol txhim kho cov tsos mob ntawm osteoarthritis tshwm sim los ntawm monosodium iodoacetate.

 

Adelmidrol (1675-66-7) Daim ntawv thov?

Adelmidrol yog ib tug semisynthetic derivative ntawm azelaic acid thiab analogue ntawm anti-inflammatory compound palmitoylethanolamide (PEA), aliamide thiab cov tswv cuab ntawm tsev neeg ntawm fatty acid amide signaling molecules nrog cannabimimetic zog. Cov tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob ntawm aliamides PEA thiab adelmidrol tau pom nyob rau hauv ntau cov kev tshawb fawb ua ntej, ob qho tib si hauv vitro thiab hauv vivo. Lawv qhov kev ua tau xav tias yog vim li cas, tsawg kawg ntawm ib feem, rau lawv lub peev xwm los txo qis-modulate mast cell activation thiab mast cell mediator tso tawm hauv pathophysiological thiab pathological mob.

 

Adelmidrol hmoov kev muag khoom(Qhov twg Yuav Adelmidrol hmoov hauv ntau)

Peb lub tuam txhab txaus siab rau kev sib raug zoo ntev nrog peb cov neeg vim tias peb tsom mus rau cov neeg siv khoom thiab muab cov khoom zoo. Yog tias koj txaus siab rau peb cov khoom lag luam, peb yoog tau nrog kho kom haum cov kev txiav txim siab kom haum koj cov kev xav tau tshwj xeeb thiab peb lub sijhawm ceev ceev ntawm kev txiav txim tau lees tias koj yuav tau saj zoo peb cov khoom kom raws sijhawm. Peb kuj tseem tsom rau kev pabcuam ntxiv tus nqi. Peb muaj nyob rau cov lus nug kev pabcuam thiab cov ntaub ntawv los txhawb koj txoj kev lag luam.

Peb yog cov kws tshaj lij Adelmidrol hmoov cov khoom lag luam rau ntau xyoo, peb muab cov khoom lag luam nrog tus nqi sib tw, thiab peb cov khoom yog cov khoom zoo tshaj plaws thiab ua tiav kev soj ntsuam nruj, ywj siab los xyuas kom meej tias nws muaj kev nyab xeeb rau kev noj thoob ntiaj teb.

 

References

  1. Cerrato, Santiago; Brazis, Pilar; della Valle, Maria Federica; Miolo, Alda; Puigdemont, Anna (2012). "Inhibitory effect of topical Adelmidrol on antigen-induced skin wheal and mast cell behaviour in a canine model of allergic dermatitis." BMC Veterinary Research. 8 (1): 230. doi: 10.1186/1746-6148-8-230. PMC 3540011. PIB 23181761.
  2. Cordaro, M. Impellizzeri, D; Gugliandolo, E; Siracusa, R; Crupi, R; Esposito, E; Cuzzocrea, S (2016). "Adelmidrol, Palmitoylethanolamide Analogue, raws li Kev Kho Mob Kho Mob Tshiab rau Kev Tswj Xyuas Kab Mob Hlwb". Molecular Pharmacology. 90 (5): 549–561. doi: 10.1124/mol.116.105668. PIB 27625036.
  3. Abramo, F; Salluzzi, D; Leotta, R; Auxilia, S; Noli, C; Miolo, A; Mantis, P; Lloyd, D. H. (2008). "Mast cell morphometry thiab densitometry hauv kev sim cov tawv nqaij qhov txhab kho nrog cov gel uas muaj adelmidrol: Txoj kev tshawb nrhiav placebo." Kev Kho Mob: Ib Daim Ntawv Qhia Txog Kev Tshawb Fawb thiab Kev Ua Haujlwm. 20 (6): 149–57 : kuv. PIB 25942520.

 


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