Coluracetam (135463-81-9)

Tej zaum 8, 2021

Cofttek yog qhov zoo tshaj plaws Coluracetam hmoov chaw tsim tshuaj paus hauv Suav teb. Peb lub Hoobkas muaj kev ua tiav kev tswj hwm kev tsim khoom (ISO9001 & ISO14001), nrog lub peev xwm tsim khoom txhua hli ntawm 160kg.

 


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 1kg / hnab, 25kg / Nruas

Coluracetam (135463-81-9) Specifications

Lub npe: Coluracetam
CAS: 135463-81-9
purity 98%
Cov mis qauv: C19H23N3O3
Lub cev nyhav: 341.411 g / moll
Melt Point: N / A
Tshuaj lub npe: N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide

MKC-231

nco -540

txhais: Coluracetam; BCI-540; MKC-231; BCI 540; MKC 231; BCI540; MKX 231.
Qhov tseem ceeb hauv InChI: PSPGQHXMUKWNDI-UHFFFAOYSA-N
Ib nrab neej: N / A
Dej Cev: Soluble hauv DMSO
Cia Kev Mob: Qhuav, tsaus thiab nyob rau hauv 0 - 4 C rau lub sij hawm luv (hnub mus rau lub lis piam) lossis -20 C rau lub sij hawm ntev (hli txog xyoo)
daim ntawv thov: Raw Coluracetam hmoov (MKC-231) yog cov khoom siv tshuaj tua hluavtaws sib xyaw ua ke kom muaj ib qhov chaw tsis muaj nootropic.
tsos: dawb crystalline hmoov

 

Coluracetam (135463-81-9) NMR Spectrum

Coluracetam (135463-81-9) NMR Spectrum

Yog tias koj xav tau COA, MSDS, HNMR rau txhua qhov khoom seem thiab lwm yam ntaub ntawv, thov hu rau peb tus thawj tswj kev lag luam.

 

Yuav ua li cas yog Coluracetam (135463-81-9)?

Raw Coluracetam hmoov (MKC-231) yog cov khoom siv tshuaj tua hluavtaws sib xyaw ua ke kom muaj ib qhov chaw tsis muaj nootropic. Nws tsis muaj lub pov thawj loj ntawm nws cov ntaub ntawv tshawb nrhiav, tab sis cov mechanisms ntawm kev ua yeeb yam (zoo li cov txheej txheem) zoo li txawv txav ntawm lwm cov npe racetam xws li Piracetam lossis Aniracetam.

Raw Coluracetam hmoov zoo nkaus li ua ke nrog cov txheej txheem hu ua high affinity choline uptake (HACU rau luv luv), uas yog tus nqi limiting ntawm cov kos duab choline mus rau hauv ib lub neuron rau synthesis mus rau hauv cov neurotransmitter acetylcholine. Nce tus HACU tus nqi txhawm rau ua rau kev ua haujlwm ntawm cholinergic neurons, yog li nws yog ib lub hom phiaj rau kev paub zoo.

 

Coluracetam (135463-81-9) cov kev pab cuam

  • Txhim Kho Kev Nco thiab Kev Kawm
  • Txhim Kho Kev Nkag Siab Nyeem Ntawv thiab Rov Cim Dawb
  • Lub Sij Hawm Rau Kev Txawj Ntev ntev
  • Txo Kho-Tiv Thaiv Kev Nyuaj Siab
  • Peev xwm Neurogenesis qib
  • Muaj peev xwm txhim kho Kev Puas Hlwb
  • Thov Kom Txhim Kho Lub Zeem Muag
  • Chim siab plob tsis so tswj tsos mob txhim kho cov tsos mob
  • Coluracetam ua si siv

 

Coluracetam (135463-81-9) siv

Coluracetam (INN) (tus lej npe BCI-540; yav tas los MKC-231) hmoov yog tus neeg sawv cev ntawm cov racetam tsev neeg. Nws tau pib tsim thiab sim los ntawm Mitsubishi Tanabe Pharma Corporation rau Alzheimer tus kab mob. Tom qab cov tshuaj tsis ua tiav rau kev xaus rau nws cov kev sim tshuaj kho mob nws tau raug tso cai los ntawm BrainCells Inc rau kev tshawb xyuas rau qhov kev tsis txaus siab loj (MDD), uas tau dhau los ua ntej tau txais txiaj ntsig "Tsim Kho Kev Tshawb Fawb Kev Tshawb Nrhiav Qhov Peev" los ntawm lub xeev California.

 

Coluracetam (135463-81-9) ntau npaum

Feem ntau ntawm cov kev tshawb fawb ntawm coluracetam tau ua rau cov tsiaj tsis muaj tib neeg, yog li tsis muaj kev cai noj qab haus huv thoob ntiaj teb. Kev siv ntau npaum li cas feem ntau yog piav raws li 5-20 mg. Cov neeg siv ntawm coluracetam tau tshaj tawm ntau cov tshuaj siv txhaj tshuaj los ntawm kev hais lus thiab kev sublingually.

Cov neeg siv cov lus taw qhia kuj tau hais tias kam rau coluracetam hmoov tuaj yeem txhim kho tau sai. Ib yam li txhua yam tshuaj, tshwj xeeb tshaj yog cov tshuaj nootropics, nws zoo tshaj yog pib ntawm kev noj tshuaj me dua thiab nce cov koob tshuaj kom tsawg zuj zus thaum koj lub cev hnov ​​mob thiab kho rau cov tshuaj. Coluracetam tsis muaj tshuaj lom thiab suav tias yog kev ua kom zoo thiab nyab xeeb.

 

Coluracetam hmoov kev muag khoom(Qhov twg Yuav Coluracetam hmoov nyob hauv ntau)

Peb lub tuam txhab txaus siab rau kev sib raug zoo ntev nrog peb cov neeg vim tias peb tsom mus rau cov neeg siv khoom thiab muab cov khoom zoo. Yog tias koj txaus siab rau peb cov khoom lag luam, peb yoog tau nrog kho kom haum cov kev txiav txim siab kom haum koj cov kev xav tau tshwj xeeb thiab peb lub sijhawm ceev ceev ntawm kev txiav txim tau lees tias koj yuav tau saj zoo peb cov khoom kom raws sijhawm. Peb kuj tseem tsom rau kev pabcuam ntxiv tus nqi. Peb muaj nyob rau cov lus nug kev pabcuam thiab cov ntaub ntawv los txhawb koj txoj kev lag luam.

Peb yog tus kws tshaj lij Coluracetam hmoov tsum tau ntau xyoo, peb muab cov khoom lag luam nrog cov nqi sib tw, thiab peb cov khoom yog qhov ua tau zoo tshaj plaws thiab muaj kev nruj me ntsis, kuaj kev ywj pheej kom ntseeg tau tias nws muaj kev nyab xeeb rau noj thoob ntiaj teb.

 

References

[1] Akaike A, li al. (1998). Kev tiv thaiv zoo ntawm MKC-231, ib qho tshiab siab sib thooj choline uptake enhancer, ntawm glutamate cytotoxicity hauv kab lis kev cai cortical neurons. Jpn J Pharmacol.

[2] Bessho, T., Takashina, K., Tabata, R., Ohshima, C., Chaki, H., Yamabe, H., Egawa, M., Tobe, A., & Saito, K. (1996). Kev cuam tshuam ntawm qhov tshiab siab sib xws choline uptake enhancer 2- (2-oxopyrrolidin-1-yl) -N- (2,3-dimethyl-5,6,7,8-tetrahydrofuro [2,3-b] quinolin-4- yl) acetoamide txog kev tiv thaiv ntawm kev tshawb dej tshawb hauv cov nas. Arzneimittel-Forschung, 46 (4), 369–373.

[3] Murai, S., Saito, H., Abe, E., Masuda, Y., Odashima, J., & Itoh, T. (1994). MKC-231, choline uptake txhim kho, ameliorates ua haujlwm lub cim xeeb ua kom tsawg thiab txo qis hippocampal acetylcholine ntxias los ntawm ethylcholine aziridinium ion hauv cov nas. Phau Ntawv Xov Xwm Txog Kev Thauj Khoom Neural, 98 (1), 1–13.doi: 10.1007 / bf01277590.

[4] Takashina K, Bessho T, Mori R, Eguchi J, Saito K. MKC-231, choline tuaj yeem txhim kho: (2) Cuam Tshuam thiab tso cov tshuaj acetylcholine hauv AF64A-kho cov nas. J Neural Transm (Vienna). 2008 Jul; 115 (7): 1027-35. doi: 10.1007 / s00702-008-0048-1. PubMed PMID: 18446264.

[5] Shirayama Y, Yamamoto A, Nishimura T, Katayama S, Kawahara R. Tom qab kis tau tus choline uptake enhancer MKC-231 antagonizes phencyclidine-induced tus cwj pwm tsis txaus thiab txo qis hauv septal cholinergic neurons hauv nas. Eur Neuropsychopharmacol. 2007 Sep; 17 (9): 616-26. PubMed PMID: 17467960.