DAWB LUB HAIV NEEG

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Lub cev metabolism hauv lub cev
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Cov pa phem
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Ultraviolet hluav taws xob
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Hnyav hlau ua qias tuaj
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Tshuaj tua kab tsis huv
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Tshuaj tua kab tsis huv

 

 

DAWB LUB CAIJ & Cov teeb meem

 

Nquag, dawb radicals yog tsim nyog rau lub cev, tab sis cov dawb radicals ntau dhau tuaj yeem ua rau lub cev tsis txaus ntawm lub zog ua haujlwm, tom qab ntawd coj mus rau oxidative kev nyuaj siab hloov zuj zus hauv ntau yam kab mob (cov ntawv nyeem qhia tau tias dawb radicals yog qhov ntawm ntau yam kab mob).

 

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TSO CAI

 

Peb lub cev tsis tuaj yeem ua haujlwm tsis muaj oxygen, thiab ib zaug muaj ntau cov dawb radicals ntau zog, lub cev nyob rau hauv oxidative kev ntxhov siab yuav ua rau kev kho kom ua tsis tiav hauv kev tshem tawm cov radicals dawb. Qee qhov tshwj xeeb, lub cev xav tau cov tshuaj tua kab mob antioxidant hauv vitro kom tshem tawm cov dawb radicals ntev dhau lawm.

 

Kev Loj Hlob Ntawm Cov Tshuaj Tiv Thaiv

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L-KEV TXHAWJ XEEM A TSHIAB HOM TXUJ CI LOS TXHUA COV NTSEEG

 

EGT yog lub ntuj chiral amino-acid antioxidant biosynthesized hauv qee yam kab mob thiab hu ua fungi. Nws yog ib qho tseem ceeb bioactive compound uas tau siv los ua cov radical scavenger, ultraviolet ray lim, lub chaw tswj hwm ntawm oxidation-txo cov tshuaj tiv thaiv thiab cellular bioenergetics, thiab lub cev cytoprotector, thiab lwm yam.
L-Ergothioneine (EGT, ERGO, CAS: 497-30-3), tseem hu ua (S) -α-Carboxy-2,3-dihydro-N, N, N-trimethyl-2-thioxo-1H-imidazole- 4-ethanaminium sab hauv ntsev, tau pib tawm los ntawm ergot los ntawm Tanret C hauv xyoo 1909, tom qab ntawd nws tseem tau tshawb pom hauv cov ntshav tsiaj. Kev ntshiab EGT yog dawb siv lead ua, soluble hauv dej, (yaj 0.9mol / L ntawm chav sov). Autoxidation tsis tuaj yeem tshwm sim ntawm physiological pH tus nqi lossis hauv cov tshuaj alkaline muaj zog. EGT tuaj yeem muaj nyob hauv ob daim isomer - ib daim thiol thiab thione form, raws li qhia hauv qab no:

 

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TXHEEJ TXHEEM

Nrog qhov zoo ntawm cov haujlwm ntau, EGT sawv ntawm ntau lwm cov antioxidants.

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POM ZOO

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Nrog rau qhov zoo ntawm ntau txoj haujlwm, EGT sawv tawm ntawm ntau lwm yam antioxidants.Qhov zoo (piv nrog glutathione, cysteine ​​thiab lwm yam):
——EGEG yuav yooj yim rau cov hlwb thiab cov concentration ntau dua ruaj khov lwm cov tshuaj tiv thaiv kab mob.
——EGEG zoo dua rau kev txo qis kev tuag ntawm tes los ntawm pyrogallol.
——EGT tsuas yog scavenges ROS kom tiv thaiv oxidation, thaum glutathione thiab lwm tus tau scavenge dawb radicals, uas yog, lwm yam antioxidants scavenge oxidation cov khoom.

COMPARISON NTAWM COV TXHEEJ TXHEEM

tau: EGT tau tshaj tawm kev nquag ntawm cov dawb radicals piv rau cov tshuaj tiv thaiv antioxidant li GSH, uric acid thiab trolox. Hauv tshwj xeeb, lub siab tshaj plaws cov tshuaj tiv thaiv antioxidant muaj peev xwm nthuav tawm los ntawm EGT vs. peroxyl radicals ua rau 25% siab dua tus nqi tau txais nrog kev siv antioxidant trolox. Qhov muaj peev xwm sib ntawm EGT rau hydroxyl radicals yog 60% siab dua, piv rau cov uric acid, uas sawv cev rau kev siv antioxidant thiab hydroxyl radicals. Thaum kawg, EGT pom tias muaj cov tshuaj tiv thaiv antioxidant ntau tshaj plaws rau peroxynitrite, nrog qhov muaj peev xwm faib 10% siab dua li ntawm uric acid.

 

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LWM LUB LAUS

 

EGT kuj tseem muaj qhov cuam tshuam los tswj kev siv lub zog nyob hauv intracellular,
txhim kho kev tiv thaiv,
txhim kho cov ciaj sia taus ntawm phev,
tiv thaiv daim siab los ntawm kev raug mob,
inhibiting mob,
tshuaj neurodegeneration,
kev loj hlob tsis xws luag thiab mob cataract.

 

 

KEV KOOM SIAB KEV LAG LUAM

G EGT TAU TXOJ CAI RAU YOOJ YIM HAIV NEEG RAU YAM THIAB TSIAJ

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STR QHIA

5-10mg ib pawg rau cov neeg laus thiab 2-3 units txuas ntxiv noj haus yog qhov tseem ceeb hauv koj kev noj zaub mov txhua hnub.

Tau qhov twg los: Li Yiqun, Zhou Nianbo. Kev Ua Yeeb Yam Ib Ce thiab Kev Siv EGT [J]. Khoom Noj Khoom Haus Engineering , 2010,9 (3) : 26-28.

Cov nkag tau muaj npe raws li hauv qab no:

Cov menyuam yaus (3-11 xyoos) L 0 mg / hnub
Cov Hluas (11-21 xyoos) ≤30 mg / hnub
Cov Neeg Loj (21-80 xyoo) ≤30 mg / hnub

Ceeb toom : 1. Cov koob tshuaj rau cov menyuam yaus thiab cov neeg laus-3 -80 xyoo)

           2.Siv rau cov poj niam cev xeeb tub lossis pub mis.

Cov ntaub ntawv peev txheej: Tetrahedron thaum thov rau Asmeskas NDI

Cov ntaub ntawv hais qhia: 10.5mg / g rau OXIS's ADI (Txais Tau Txais Txhua Hnub).

 

③ SYNTHESIS

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TSHAWB & UA NTAWV

(1) NTXHUAB

Tam sim no, muaj peb txoj hauv kev rau cov khoom EGT: hluavtaws ua haujlwm, tej yam ntuj tso tso xyoob tawm (feem ntau yog los ntawm nceb, tsiaj cov nqaij thiab ntshav ntxiv), thiab txoj kev siv tshuaj tua kab mob biosynthesis

Sib Piv ntawm EGT Kev Muab Extraction txoj kev

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(2) DAIM NTAWV THOV

EGT muaj cov ntawv thov dav dav hauv cov tshuaj pleev ib ce, tej zaub mov, tshuaj lag luam, tshuaj kho mob, biomedicine, thiab lwm yam.

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(3) LWM YAM KEV TSIM NYOG

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References
  1. Oleoylethanolamide (oea) - uas yog tej yam hauv koj lub neej
  2. Anandamide vs cbd: uas ib qho zoo dua rau koj li kev noj qab haus huv? Txhua yam koj yuav tsum paub txog lawv!
  3. Everything you need to know about nicotinamide riboside chloride
  4. Magnesium l-threonate supplements: benefits, dosage, and side effects
  5. Palmitoylethanolamide (pea): benefits, dosage, uses, supplement
  6. Top 6 health benefits of resveratrol supplements
  7. Top 5 benefits of taking phosphatidylserine (ps)
  8. Top 5 benefits of taking pyrroloquinoline quinone (pqq)
  9. The best nootropic supplement of alpha gpc in 2020
  10. The best anti-aging supplement of nicotinamide mononucleotide(nmn) in 2020

 

txheem